The diagnostic value of metagenomic next-generation sequencing for identifying Streptococcus pneumoniae in paediatric bacterial meningitis

Table 3 Diagnostic performance of mNGS compared with culture and Alere BinaxNow® Streptococcus pneumoniae Antigen test for the detection of Streptococcus pneumoniae

Clinical microbiology tests	mNGS
Clinical microbiology tests	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Culture^a	73.1	88.1	59.4	93.2
Combined test^b	70.3	93.9	81.3	89.3

Note: ^arefers to the blood and/or CSF culture; ^brefers to culture and or Alere BinaxNow® Streptococcus pneumoniae Antigen test. PPV positive predictive value, NPV negative predictive value

ISSN: 1471-2334