In vitro activities of Eravacycline against 336 isolates collected from 2012 to 2016 from 11 teaching hospitals in China

Table 4 MIC distribution of Eravacycline and relevant antibiotics against A. baumannii of different resistance characteristics

Antibiotics	Sensitive ^a, n = 9			OXA-23 positive, n = 21			Tigecycline resistant, n = 9
Antibiotics	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range
Eravacycline	0.125	0.25	0.016–0.25	1	2	0.5–2	2	2	2–4
Tigecycline	0.25	0.5	0.25–0.5	4	4	4–8	8	8	8–8
Piperacillin/Tazobactam	2	4	0.016–8	256	256	256–256	256	256	256–256
Ceftazidime	2	8	0.125–32	256	256	64–256	256	256	256–256
Cefepime	1	4	0.032–32	64	256	32–256	256	256	128–256
Imipenem	0.125	1	0.125–1	64	64	16–64	64	64	64–128
Meropenem	0.032	1	0.016–1	32	64	16–64	64	64	32–128
Colistin	0.125	0.25	0.125–0.25	0.25	0.25	0.125–0.25	0.25	0.25	0.25–0.25
Amikacin	4	4	1–4	256	256	256–256	256	256	256–256
Minocycline	0.125	16	0.064–16	8	16	4–16	8	8	8–16
Ciprofloxacin	0.125	0.5	0.032–32	32	32	32–32	32	32	32–32
Levofloxacin	0.125	1	0.064–32	16	32	8–32	16	16	16–32

^a: Sensitive strains referred to strains do not have carbapenem resistance and tigecycline resistance

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