From: Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study
Variables | Sputum culture positive n = 279 | Sputum culture negative/Bronchoscopy n = 21 | Scanty sputum/Bronchoscopy n = 47 | P-value |
---|---|---|---|---|
Sex, female | 176 (63.1) | 10 (47.6) | 29 (61.7) | 0.371 |
Age, years | 67 (59, 74) | 64 (60, 76) | 66 (57, 73) | 0.593 |
Smoking history | 0.919 | |||
 Never smoker | 209 (74.6) | 15 (71.4) | 35 (74.5) |  |
 Former smoker | 63 (22.6) | 5 (23.8) | 11 (23.4) |  |
 Current smoker | 9 (2.9) | 1 (4.8) | 1 (2.1) |  |
History of tuberculosis | 116 (41.6) | 6 (28.6) | 9 (19.2) | 0.034 |
Smear-positive upon diagnosis | 47 (16.9) | 2 (9.5) | 13 (27.7) | 0.311 |
Underlying disease | ||||
 COPD | 28 (10.0) | 3 (14.3) | 1 (2.1) | 0.092 |
 GERD | 23 (8.2) | 1 (4.8) | 3 (6.4) | 0.712 |
 Cancer | 18 (6.5) | 3 (14.3) | 1 (2.1) | 0.155 |
 Diabetes mellitus | 16 (5.7) | 4 (19.1) | 2 (4.3) | 0.069 |
Radiographic subtype | 0.475 | |||
 Nodular bronchiectatic | 251 (90.0) | 19 (90.5) | 45 (95.7) |  |
 Upper lobe cavitary | 29 (10.0) | 2 (9.5) | 2 (4.3) |  |
Cough | 0.004 | |||
 None | 90 (32.3) | 8 (38.1) | 31 (66.0) |  |
 Sometimes | 67 (24.0) | 5 (23.8) | 5 (10.6) |  |
 Often | 46 (16.5) | 3 (14.3) | 5 (10.6) |  |
 Almost everyday | 76 (27.2) | 5 (23.8) | 6 (12.8) |  |
Sputum | < 0.001 | |||
 None | 66 (23.7) | 13 (61.9) | 26 (55.3) |  |
  ≤ 3 days per week | 43 (15.4) | 2 (9.5) | 8 (17.0) |  |
  ≥ 4 days per week | 30 (10.8) | 1 (4.8) | 4 (8.5) |  |
 Almost everyday | 140 (50.2) | 5 (23.8) | 9 (19.2) |  |
mMRC dyspnoea scale | 0.806 | |||
 0 | 102 (36.7) | 7 (33.3) | 22 (46.8) |  |
 1 | 159 (57.2) | 14 (66.7) | 24 (51.1) |  |
 2 | 14 (5.0) | 0 (0.0) | 1 (2.1) |  |
 3 | 2 (0.7) | 0 (0.0) | 0 (0.0) |  |
 4 | 1 (0.4) | 0 (0.0) | 0 (0.0) |  |
Haemoptysis | 50 (17.9) | 5 (23.8) | 8 (17.0) | 0.792 |
Postnasal drip | 84 (30.1) | 3 (14.3) | 5 (10.6) | 0.015 |
SGRQ score | 17.6 (9.5, 32.4) | 12.6 (6.9, 21.0) | 9.2 (4.1, 17.5) | < 0.001 |
Fever | 32 (11.5) | 3 (14.3) | 4 (8.5) | 0.807 |
Weight loss | 25 (9.0) | 1 (4.8) | 4 (8.5) | > 0.999 |
Anxiety scale | 5 (2, 7) | 4 (2, 7) | 5 (2, 6) | 0.872 |
Depression scale | 5 (2, 8) | 5 (3, 7) | 5 (3, 7) | 0.917 |