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Table 4 Characteristics of 347 patients diagnosed with nontuberculous mycobacterial pulmonary disease according to three groups of patients

From: Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study

Variables Sputum culture positive
n = 279
Sputum culture negative/Bronchoscopy
n = 21
Scanty sputum/Bronchoscopy
n = 47
P-value
Sex, female 176 (63.1) 10 (47.6) 29 (61.7) 0.371
Age, years 67 (59, 74) 64 (60, 76) 66 (57, 73) 0.593
Smoking history 0.919
 Never smoker 209 (74.6) 15 (71.4) 35 (74.5)  
 Former smoker 63 (22.6) 5 (23.8) 11 (23.4)  
 Current smoker 9 (2.9) 1 (4.8) 1 (2.1)  
History of tuberculosis 116 (41.6) 6 (28.6) 9 (19.2) 0.034
Smear-positive upon diagnosis 47 (16.9) 2 (9.5) 13 (27.7) 0.311
Underlying disease
 COPD 28 (10.0) 3 (14.3) 1 (2.1) 0.092
 GERD 23 (8.2) 1 (4.8) 3 (6.4) 0.712
 Cancer 18 (6.5) 3 (14.3) 1 (2.1) 0.155
 Diabetes mellitus 16 (5.7) 4 (19.1) 2 (4.3) 0.069
Radiographic subtype 0.475
 Nodular bronchiectatic 251 (90.0) 19 (90.5) 45 (95.7)  
 Upper lobe cavitary 29 (10.0) 2 (9.5) 2 (4.3)  
Cough 0.004
 None 90 (32.3) 8 (38.1) 31 (66.0)  
 Sometimes 67 (24.0) 5 (23.8) 5 (10.6)  
 Often 46 (16.5) 3 (14.3) 5 (10.6)  
 Almost everyday 76 (27.2) 5 (23.8) 6 (12.8)  
Sputum < 0.001
 None 66 (23.7) 13 (61.9) 26 (55.3)  
  ≤ 3 days per week 43 (15.4) 2 (9.5) 8 (17.0)  
  ≥ 4 days per week 30 (10.8) 1 (4.8) 4 (8.5)  
 Almost everyday 140 (50.2) 5 (23.8) 9 (19.2)  
mMRC dyspnoea scale 0.806
 0 102 (36.7) 7 (33.3) 22 (46.8)  
 1 159 (57.2) 14 (66.7) 24 (51.1)  
 2 14 (5.0) 0 (0.0) 1 (2.1)  
 3 2 (0.7) 0 (0.0) 0 (0.0)  
 4 1 (0.4) 0 (0.0) 0 (0.0)  
Haemoptysis 50 (17.9) 5 (23.8) 8 (17.0) 0.792
Postnasal drip 84 (30.1) 3 (14.3) 5 (10.6) 0.015
SGRQ score 17.6 (9.5, 32.4) 12.6 (6.9, 21.0) 9.2 (4.1, 17.5) < 0.001
Fever 32 (11.5) 3 (14.3) 4 (8.5) 0.807
Weight loss 25 (9.0) 1 (4.8) 4 (8.5) > 0.999
Anxiety scale 5 (2, 7) 4 (2, 7) 5 (2, 6) 0.872
Depression scale 5 (2, 8) 5 (3, 7) 5 (3, 7) 0.917
  1. Values are presented as number (percentage) or median (interquartile range)
  2. Abbreviations: COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, mMRC modified medical research council, SGRQ St. George’s Respiratory Questionnaire