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Table 4 Characteristics of 347 patients diagnosed with nontuberculous mycobacterial pulmonary disease according to three groups of patients

From: Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study

Variables

Sputum culture positive

n = 279

Sputum culture negative/Bronchoscopy

n = 21

Scanty sputum/Bronchoscopy

n = 47

P-value

Sex, female

176 (63.1)

10 (47.6)

29 (61.7)

0.371

Age, years

67 (59, 74)

64 (60, 76)

66 (57, 73)

0.593

Smoking history

0.919

 Never smoker

209 (74.6)

15 (71.4)

35 (74.5)

 

 Former smoker

63 (22.6)

5 (23.8)

11 (23.4)

 

 Current smoker

9 (2.9)

1 (4.8)

1 (2.1)

 

History of tuberculosis

116 (41.6)

6 (28.6)

9 (19.2)

0.034

Smear-positive upon diagnosis

47 (16.9)

2 (9.5)

13 (27.7)

0.311

Underlying disease

 COPD

28 (10.0)

3 (14.3)

1 (2.1)

0.092

 GERD

23 (8.2)

1 (4.8)

3 (6.4)

0.712

 Cancer

18 (6.5)

3 (14.3)

1 (2.1)

0.155

 Diabetes mellitus

16 (5.7)

4 (19.1)

2 (4.3)

0.069

Radiographic subtype

0.475

 Nodular bronchiectatic

251 (90.0)

19 (90.5)

45 (95.7)

 

 Upper lobe cavitary

29 (10.0)

2 (9.5)

2 (4.3)

 

Cough

0.004

 None

90 (32.3)

8 (38.1)

31 (66.0)

 

 Sometimes

67 (24.0)

5 (23.8)

5 (10.6)

 

 Often

46 (16.5)

3 (14.3)

5 (10.6)

 

 Almost everyday

76 (27.2)

5 (23.8)

6 (12.8)

 

Sputum

< 0.001

 None

66 (23.7)

13 (61.9)

26 (55.3)

 

  ≤ 3 days per week

43 (15.4)

2 (9.5)

8 (17.0)

 

  ≥ 4 days per week

30 (10.8)

1 (4.8)

4 (8.5)

 

 Almost everyday

140 (50.2)

5 (23.8)

9 (19.2)

 

mMRC dyspnoea scale

0.806

 0

102 (36.7)

7 (33.3)

22 (46.8)

 

 1

159 (57.2)

14 (66.7)

24 (51.1)

 

 2

14 (5.0)

0 (0.0)

1 (2.1)

 

 3

2 (0.7)

0 (0.0)

0 (0.0)

 

 4

1 (0.4)

0 (0.0)

0 (0.0)

 

Haemoptysis

50 (17.9)

5 (23.8)

8 (17.0)

0.792

Postnasal drip

84 (30.1)

3 (14.3)

5 (10.6)

0.015

SGRQ score

17.6 (9.5, 32.4)

12.6 (6.9, 21.0)

9.2 (4.1, 17.5)

< 0.001

Fever

32 (11.5)

3 (14.3)

4 (8.5)

0.807

Weight loss

25 (9.0)

1 (4.8)

4 (8.5)

> 0.999

Anxiety scale

5 (2, 7)

4 (2, 7)

5 (2, 6)

0.872

Depression scale

5 (2, 8)

5 (3, 7)

5 (3, 7)

0.917

  1. Values are presented as number (percentage) or median (interquartile range)
  2. Abbreviations: COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, mMRC modified medical research council, SGRQ St. George’s Respiratory Questionnaire