Skip to main content

Table 1 Baseline demographic and clinical characteristics of patients before and after propensity score matched analysis

From: Acute kidney injury during daptomycin versus vancomycin treatment in cardiovascular critically ill patients: a propensity score matched analysis

  Before matching Propensity score matched
Characteristics DAP (N = 28) VAN (N = 44) p DAP (N = 16) VAN (N = 16) p
Male sex, n (%) 17 (61) 34 (77) .215 10 (63) 11 (69) 1
Age, y 60.0 [52.3–70.5] 63.0 [54.0–75.3] .206 56.0 [49.5–69.3] 65.0 [49.0–78.0] .086
Weight, kg 74.0 [61.5–80.5] 72.0 [64.5–80.0] .827 71.5 [61.5–79.3] 75.0 [63.0–85.3] .383
Height, cm 170 [163–173] 167 [165–175] .821 170 [165–174] 167 [161–169] .179
History of CRcl < 50 ml/min, n (%) 8 (28.6) 5 (11.4) .125 2 (12.5) 2 (12.5) 1
History of diabetes mellitus, n (%) 10 (35.7) 11 (25.0) .478 4 (25.0) 6 (37.5) .704
History of hypertension 10 (35.7) 23 (52.3) .258 5 (31.3) 8 (50.0) .473
Heart failure (EF < 50%), n (%) 18 (64.3) 16 (36.4) .038 12 (75.0) 4 (25.0) .012
CPB during surgery, n (%) 9 (32.1) 25 (56.8) .071 7 (43.8) 7 (43.8) 1
VAD, n (%) 7 (25) 7 (15.9) .519 5 (31.3) 1 (6.3) .172
Circulatory shock at baseline, n (%) 8 (28.6) 21 (47.8) .171 4 (25.0) 9 (56.3) .149
Others nephrotoxic agentsa, n (%) 18 (64.3) 29 (65.9) .910 9 (56.3) 11 (68.7) .716
SAPS II score at ICU admission 44.5 [35.3–57.8] 45.5 [34.0–57.8] .894 51.0 [38.5–61.5] 48.0 [35.0–57.0] .984
SOFA score at baseline 5 [2–9] 6 [3–9] .388 4 [2–7] 6 [3–8] .281
Serum creatinine at baseline, μmol/l 110 [77–142] 99 [72–134] .699 87 [64–126] 94 [69–124] .440
AKI at baseline, n (%) 7 (25.0) 13 (29.5) .881 2 (12.5) 6 (37.5) .220
Previous antibiotic treatment, n (%) 19 (67.8) 24 (54.5) .381 8 (50) 8 (50) 1
GPC bacteraemia, n (%) 16 (57.1) 12 (27.3) .022 11 (68.8) 10 (62.5) .710
  1. Quantitative data are expressed as median [interquartile range]. Baseline is the time of treatment initiation
  2. aWithin 2 days before or after initiation of treatment
  3. DAP daptomycin, VAN vancomycin, CRcl creatinine clearance, EF ejection fraction, CPB cardiopulmonary bypass, VAD ventricular assist device, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, AKI acute kidney injury, GPC Gram positive cocci