Evaluation of risk factors associated with drug-resistant tuberculosis in Yemen: data from centres with high drug resistance

Table 6 Predictors of unsuccessful treatment outcomes, as determined by simple logistic regression

Variable	Treatment outcome		β	SE	p-Value^a	OR (95% CI)
Variable	Unsuccessful (N = 26)	Successful (N = 89)	β	SE	p-Value^a	OR (95% CI)
Age (years)
≤ 45	8	62				Ref
> 45	18	27	0.722	1.52	0.636	0.486 (0.24–9.7)
Baseline weight (kg)
> 40	13	23				Ref
≤ 40	13	66	3.83	1.77	0.031	4.1 (1.43–14.8)
Comorbidity
No	7	78				Ref
Yes	19	11	2.939	1.461	0.044	18.8 (1.01–33.7)
Baseline lung cavities
No	2	66				Ref
Yes	23	24	2.889	1.377	0.036	17.9 (1.20–26.7)
Creatinine level
Normal	17	88				Ref
Above normal	1	9	−0.347	1.11	0.75	0.71 (0.081–6.2)
History of streptomycin use
No	18	74				Ref
Yes	8	15	1.99	1.210	0.100	7.3 (0.68–78)
Positive culture, end of I.P.
No	64	3				Ref
Yes	25	23	2.667	1.112	0.016	14 (1.62–127)
History of failed TB treatment
No	5	58				Ref
Yes	21	31	1.174	0.975	0.229	3.23 (0.47–21.8)
Smoking status
No	1	29				Ref
Yes	25	60	1.757	1.55	0.259	3.2 (0.47–21.87)
Chewing khat^b
No	2	9				Ref
Yes	24	80	−0.806	2.043	0.693	0.4 (0.008–24.5)
Resistance to FLDs
≤ 2	17	60				Ref
> 2	9	29	−1.11	0.898	0.215	0.3 (0.05–1.911)

^ap-Values ≤0.05 are shown in bold
^bKhat is a shrub that grows in parts of East Africa and Yemen
Abbreviations: SE, standard error of the mean; OR, odds ratio; CI, confidence interval; Ref, reference group; I.P., intensive phase; FLD, first-line drug

ISSN: 1471-2334