| Conventional analyses Mean (95% CI) | BLCM Median (95% CrI) | ||
---|---|---|---|---|
Primary | Adjusted | Binary qPCR model | Continuous qPCR model | |
27 UAT positives considered true positives | UAT sensitivity is 75% and specificity is 100% | qPCR and UAT | qPCR and UAT | |
Prevalence | 8% (5–11%) | 10% (7–15%) | 10% (7–16%) | 11% (7–17%) |
Sensitivity of qPCR | 96% (81–100%) |  | 96% (83–100%) |  |
Specificity of qPCR | 74% (69–79%) |  | 75% (71–79%) |  |
PPV of qPCR | 23% (16–32%) |  | 31% (20–44%) |  |
Mean qPCR Ct among PPN | 25.6 (24.2–26.9) |  |  | 25.7 (24.6–27) |
Mean qPCR among Non-PPN | 31 (30–32) |  |  | 32.4 (31.4–33.4) |
Sensitivity of UAT | 100% (assumed) | 75% (published) | 72% (53–87%) | 67% (51–83%) |
Specificity of UAT | 100% (assumed) | 100% (assumed) | 99.5% (98.5–99.9%) | 99.5% (98.6–99.9%) |
PPV of UAT | 100% | 100% | 94% (83–99%) | 95% (83–99%) |
Probability of PPV of UAT < 90% | 0 | 0 | 18% | 17% |