|Case report||Clinical information||Infection isolate(s)||Susceptibilty profile of B. trematuma,b||Therapya||Outcome|
|Daxboeck et al. (2004) ||Male, 82-year-old, with type 2 diabetes mellitus (DM), and infected ulcer on left foot.||Bordetella trematum and Pseudomonas aeruginosa||
Susceptible to AMI, AMC, CTX, CAZ, GEN, IMI, TZP.|
Resistant to CXM and CIP.
|10-day treatment of AMC and CIP; without clinical improvement; the antimicrobial treatment was discontinued.||Favorable|
|Hernández-Porto et al. (2013) ||Female, 76-year-old, with DM, renal failure, peripheral vascular disease, and ulcers in lower extremities||B. trematum and Achromobacter xylosoxidans||
Susceptible to AMI (16 μg/mL), AMC (2 μg/mL), CAZ (8 μg/mL), GEN (4 μg/mL), IMI (0,5 μg/mL), MEM (0.125 μg/mL), TZP (1 μg/mL) and SXT (0.5 μg/mL)|
Resistant to ATM (> 32 μg/mL), CTX (> 32 μg/mL), CXM (4 μg/mL) and CIP (4 μg/mL).
|21 days with SXT and 14 days with CAZ (initiated 2 weeks after positive culture for B. trematum).||Favorable|
|Halim et al. (2014) ||Male, 60-year-old, no history of pathologies, presenting thorax burns by butane gas||B. trematum and Enterobacter cloacae in blood culture||
Susceptible to CIP, CLA, CL, DOX, IMI, MIN and NET.|
Resistant to AMI, AMC, CTX, CAZ, CF, GEN, and TOB.
|IMI, NET, and CL.||Death|
|Almagro-Molto, Eder, Schubert (Case 1) (2015) ||Male, 65-year-old, with DM, peripheral vascular disease and foot ulcer||B. trematum, Staphylococcus aureus, Proteus vulgaris, Alcaligenes faecalis and Morganella morganii||
Susceptible to AMI, AMC, AMP, CPM, GEN, IMI, LVX, MEM, MIN, PIP, TZP, SXT, TGC, and TOB.|
Resistant to CTX, FOX, CAZ, CXM, CIP, ETP, and FOS.
|Debridement and 7-day course of CIP||Persistence of infection|
|Almagro-Molto, Eder, Schubert (Case 2) (2015) ||Female, 72-year-old, suspected of osteomyelitis, bone defects in the feet and ankles, venous disorder, impaired renal function, ulcer in both feet||B. trematum, P. vulgaris and A. faecalis in both feet ulcer exsudate samples/B. trematum, MRSA, A. faecalis and S. maltophilia in the surgical sample of ulcer of both feet||
Susceptible to AMI, AMC, AMP, CPM, GENc, IMI, LVXc, MEM, MIN, PIP, TZP, SXT, TGC, and TOB.|
Intermediate to ETP and LVXc
Resistant to CTX, FOX, CAZ, CXM, CIP, FOS, and GENc.
|Compression therapy and 14-day course of CIP; despite clinical improvement, both limbs were amputated after 3 weeks; antimicrobial therapy with TZP (7 days) followed by MEM (7 days)||Favorable|
|Saksena, Manchanda, Mittal (2015) ||Young girl, 7-month-old, febrile, presenting vomiting; provisional diagnosis of infantile tremor syndrome with protein energy malnutrition and developmental delay||B. trematum in blood culture||
Susceptible to AMS (8 μg/mL), CIP (1 μg/mL), IMI (1 μg/mL), TZP (8. μg/mL) and SXT (20 μg/mL)|
Intermediate to CPM (16 μg/mL), CRO (32 μg/mL), LVX (4 μg/mL), PIP (64 μg/mL) and TOB (8 μg/mL)
Resistant to AMI (64 μg/mL), CAZ (64 μg/mL), CL (16 μg/mL), GEN (16 μg/mL), MEM (16 μg/mL)
|Empirical therapy with CRO for 5 days; then the treatment switched to TZP and AMI; on the 12th day, therapy was modified to CIP and AZM (5 days)||Favorable|
|Almuzara et al. (2015) ||Male, 14-year-old, febrile and hemodynamically unstable, presenting left hip septic arthritis. Diagnosis of chronic osteomyelitis (S. aureus)||Escherichia coli and B. trematum in bone biopsy||
Susceptible to AMI (16 μg/mL), CPM (4 μg/mL), CAZ (4 μg/mL), CF (8 μg/mL), CL (≤ 5 μg/mL), GEN (4 μg/mL), IMI (≤ 1 μg/mL), MEM (≤ 0.25 μg/mL) and SXT (≤ 2 μg/mL)|
Intermediate to AMP (16 μg/mL), AMS (16 μg/mL), CTX (32 μg/mL) and CIP (2 μg/mL)
|Multiple surgical debridement, antimicrobial treatment with MEM and SXT for 6 months; MIN later||Favorable|
|Majewski et al. (2016) ||Transgender male, 61-year-old, with below-knee amputations in both lower limbs, DM, stage IV chronic kidney disease, and coronary artery disease, with a right femur fracture after a fall, respiratory distress, septic shock and worsening of left leg wound after hospitalization||B. trematum in blood culture||
Susceptible to AMI, AMC, CAZ (8 μg/mL), CIP (0,008 μg/mL), IMI (0.25 μg/mL), LVX (0,03 μg/mL), TZP (2 μg/mL) and TOB|
Intermediate to CTX (16 μg/mL)
Resistant to CXM and GEN
|Empirical treatment with TZP and VAN; the left lower limb infection worsened, treatment switch to CIP; due to necrotizing fasciitis probability CLI was added; persistence of septic shock, TOB added||Death|
|Current report||Female, 74-year-old, with necrotic ulcers in both legs, presenting signs of local infection, systemic arterial hypertension; DM; hypothyroidism; peripheral arterial occlusive disease; stage IV chronic kidney disease||B. trematum, E. faecalis and S. maltophilia in a tissue fragment||MIC ≤025 μg/mL to TGC, CLI and PB; MIC 0.5 μg/mL to DOR; MIC 1 μg/mL to CIP, LVX, IMI and MEM; MIC 2 μg/mL to DOX, GEN, MIN, TOB and CPM; MIC 4 μg/mL to AMI and CAZ; MIC 8 μg/mL to CTX; MIC 4/2 μg/mL to AMS; MIC 8/4 μg/mL to TZP; MIC 9.5/4.5 μg/mL to SXT MIC 16/2 μg/mL to TIM; MIC > 16 μg/mL to ATM||Empirical treatment with TZP and surgical debridement; treatment switch to VAN and MEM due to septic shock; LVX added aiming S. maltophilia||Death|