Table 5 Characteristics of patients included in the IVE analysis by vaccination status
Risk variable | Category | Unvaccinated | Vaccinated | P value |
|---|---|---|---|---|
Number of patients, n (%) | Controls | 5452 (72.9) | 1250 (83.6) | < 0.001 |
Cases | 2023 (27.1) | 246 (16.4) | ||
Age (y) | Median (IQR) | 19.3 (3.0–51.9) | 74.8 (56.3–83.3) | < 0.001 |
Age group, n (%) | 6–11 months | 524 (7.0) | 14 (0.9) | < 0.001 |
1–4 y | 2370 (31.7) | 76 (5.1) | ||
5–17 y | 758 (10.1) | 136 (9.1) | ||
18–49 y | 1879 (25.1) | 114 (7.6) | ||
50–64 y | 726 (9.7) | 114 (7.6) | ||
65–74 y | 487 (6.5) | 302 (20.2) | ||
75–84 y | 513 (6.9) | 438 (29.3) | ||
≥ 85 y | 218 (2.9) | 302 (20.2) | ||
Female, n (%) | – | 3480 (46.6) | 637 (42.6) | 0.005 |
Comorbidities, n (%) | No | 5350 (71.6) | 415 (27.7) | < 0.001 |
Yes | 2125 (28.4) | 1081 (72.3) | ||
Pregnant (women 15–45 y), n (%) | – | 606 (59.4) | 8 (29.6) | 0.002 |
Obesea, n (%) | – | 1038 (13.9) | 321 (21.5) | < 0.001 |
Hospitalization within ≤12 mo, n (%) | – | 1954 (26.1) | 549 (36.7) | < 0.001 |
Outpatient consultations within ≤3 mo, n (%) | No | 2624 (35.11) | 304 (20.32) | < 0.001 |
Yes | 4850 (64.89) | 1192 (79.68) | ||
Smoking (≥ 18 y), n (%) | Current | 949 (25.0) | 186 (14.7) | < 0.001 |
Past | 924 (24.3) | 475 (37.5) | ||
Never | 1926 (50.7) | 605 (47.8) | ||
Functional impairment (≥ 65 y), n (%) | None or minimal | 471 (46.0) | 572 (58.3) | < 0.001 |
Mild | 321 (31.4) | 232 (23.7) | ||
Moderate | 98 (9.6) | 54 (5.5) | ||
Severe | 38 (3.7) | 39 (4.0) | ||
Total | 95 (9.3) | 84 (8.6) | ||
Sampling interval (d) | Median (IQR) | 3 (2–5) | 4 (2–5) | < 0.001 |
Sampling interval, n (%) | ≤ 4 d | 5139 (68.8) | 920 (61.5) | |
5–7 d | 2104 (28.2) | 475 (31.8) | ||
8–9 d | 232 (3.1) | 101 (6.8) | ||
Site, n (%) | St. Petersburg | 1645 (22.0) | 45 (3.0) | < 0.001 |
Moscow | 1808 (24.2) | 87 (5.8) | ||
Czech Republic | 115 (1.5) | 7 (0.5) | ||
France | 81 (1.1) | 60 (4.0) | ||
Turkey | 522 (7.0) | 43 (2.9) | ||
Beijing | 1854 (24.8) | 258 (17.3) | ||
Valencia | 1018 (13.6) | 931 (62.2) | ||
India | 259 (3.5) | 15 (1.0) | ||
Mexico | 87 (1.2) | 5 (0.3) | ||
Curitiba | 86 (1.2) | 45 (3.0) | ||
Vaccinated, n (%) | In 2013–2014 | 526 (7.1) | 1073 (72.8) | < 0.001 |
In 2014–2015 | 545 (7.4) | 1200 (81.2) | < 0.001 |