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Table 3 univariate & multivariate analysis to determine the risk factors for mortality among infective C. auris cases

From: Clinical spectrum and factors impacting outcome of Candida auris: a single center study from Pakistan

Category Died n = 30 (100%) Survived n = 35 (100%) Univariate Multivariable
   OR*[95% CI] P-value AOR[95% CI] P-value
Age group
 16–35 5 (16.7%) 10 (28.6%) 1.0    
 36–55 10 (33.3%) 10 (28.6%) 2.0 [0.5–7.9] 0.32   
 56–75 13 (43.3%) 08 (22.9%) 3.2 [0.8–13] 0.09 4.5 [1.09–18.9] 0.038
 76–96 02 (6.7%) 07 (20%) 0.5 [0.08–3.8] 0.56   
Location in hospital
 ICU 14 (46.7%) 09 (25.7%) 3.4 [0.8–13] 0.07 1.2 [0.24–5.8] 0.81
 Special Care 11 (36.7%) 13 (37.1%) 1.86 [0.5–7.0] 0.35   
 Ward 05 (16.7%) 11 (31.4%) 1.0 0.19   
 Outpatient 0 02 (3.1%)     
Diabetes Mellitus 11 (36.7%) 07 (20%) 2.3 [0.7–7.0] 0.13   
Malignancy 06 (20%) 06 (17.6%) 0.96 [0.20–3.2] 0.95   
Candidemia 23 (76.7%) 15 (42.9%) 4.3 [1.4–12] 0.007 4.2 [1.09–16.49] 0.03
Early blood clearance (≤72 h) 02 (18.2%) 5 (35.7%) 1.0    
Late blood clearance (> 72 h) 09 (81.8%) 9 (64.3%) 2.5 [0.38–16.42] 0.34   
No blood clearance 02 (15.4%) 0 (0)     
Appropriate antifungal therapy 23 (76.7%) 21 (60%) 2.2 [0.7–6.4] 0.15   
Early antifungal therapy 14 (46.7%) 6 (17.1%) 4.66 [1.2–17.43] 0.02 0.84 [0.16–4.3] 0.83
Late antifungal therapy 09 (30%) 15 (42.9%) 1.2 [0.3–4.09] 0.77 4.1 [0.94–17.9] 0.06
Source control 17 (42.5%) 25 (57.5%) 0.52 [0.18–1.46] 0.2 0.22 [0.05–0.92] 0.038
Early source control 07 (41.2%) 13 (56.5%) 1.0    
Late source control 10 (58.8%) 10 (43.5%) 1.5 [0.4–5.3] 0.49   
Co infection with multidrug resistant bacteria 13 (43.3%) 09 (25.7%) 2.2 [0.77–6.2] 0.13 2.7 [0.61–12.6] 0.18
  1. *OR, odds ratio
  2. †AOR, adjusted odds ratio