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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Multiplexed kit based on Luminex technology and achievements in synthetic biology discriminates Zika, chikungunya, and dengue viruses in mosquitoes

Fig. 1

Adapted from [32, 34]. Left panels: Overview of the Luminex xMAP DHAs protocol developed to detect DENV, CHIKV, and ZIKV RNAs. Right top panel: The strategic removal of hydrogen bonding groups gives a self-avoiding molecular recognition system, SAMRS. Right middle panel: The “transliteration” strategy allows a template G to direct the incorporation of the AEGIS base Z by primer extension, which exploits the mismatch between G and deprotonated Z. Right bottom panel: The artificially expanded genetic information system (AEGIS) adds up to eight nucleotides and contributes four additional base pairs to the four standard nucleotides by strategically rearranging hydrogen bonding patterns. The AEGIS Z: P pair is exploited in this work

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