Table 1 Clinical characterizations of 85 Ulcerative Colitis patients in CDI and Non CDI groups
From: Clostridium difficile isolated from faecal samples in patients with ulcerative colitis
Variables | CDI patients (15) | Non-CDI patients (70) | Univariate analysis | ||
|---|---|---|---|---|---|
Toxigenic C.difficile strains, (A + B+ or A-B+), n = 15 | Negative C.difficile strains, n = 58 | Non toxigenic strains, n = 12 | P value | ||
Count (%) | Count (%) | Count (%) | |||
Male | 8 (53.3) | 37 (63.8) | 6 (50) | 0. 08 | |
Severity of UC | Â | ||||
Mild | 0 | 38 (65.5) | 11 (91.7) | ||
Moderate to severe | 15 (100.0) | 20 (34.5) | 1 (8.3) | 0.001 | |
Previous surgery | 10 (66.7) | 16 (27.6) | 6 (50) | 0.02 | |
Antibiotic treatment within 8 weeks prior to CDI (metronidazole, Cyclosporine, Clindamycin, cephalosporin, …) | One | 4 (26.7) | 18 (31.0) | 3 (25.0) | 0.2 |
Two | 6 (40.0) | 18 (31.0) | 4 (33.3) | ||
Three | 5 (33.3) | 12 (20.7) | 4 (33.3) | ||
Steroids | 15 (100) | 20 (34.5) | 4 (33.3) | 0.001 | |
Anti-inflammatory drugs | Mesalamine | 8 (53.3) | 21 (36.2) | 4 (33.3) | 0.01 |
Sulfasalazine | 11 (73.3) | 22 (37.9) | 4 (41.7) | ||
History of colectomy | 5 (33.3) | 11(18.9) | 3 (25.0) | 0.03 | |
Age at diagnosis (years), mean ± SD | 46.5 ± 11.4 | 42.3 ± 13.1 | 41.2 ± 14.3 | 0.07 | |