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Table 3 Median IL-1β production of macrophages assessed 24 h after two hours of stimulation

From: Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis

Factor-by-Group Interleukin-1β production (in μg/mL)
Unadjusted difference in median expression Adjusted difference in median expressiona
β 95% CI P-value β 95% CI P-value
LpqH
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB infection −11.95 (−33.51, 9.61) 0.27 −9.62 (−36.41, 17.16) 0.47
 Pulmonary TB −8.95 (−38.11, 20.21) 0.54 −8.95 (−44.03, 26.13) 0.61
 Extrapulmonary TB 38.88 (8.45, 69.3) 0.01** 44.99 (−68.86, 158.86) 0.43
Gamma-irradiated M. tuberculosis
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB infection −44.28 (−88.91, 0.36) 0.05** −37.92 (−86.66, 10.81) 0.12
 Pulmonary TB −12.89 (−71.47, 45.69) 0.66 − 12.89 (− 101.65, 75.87) 0.77
 Extrapulmonary TB −16.56 (−74.34, 41.23) 0.57 −16.07 (− 143.80, 111.66) 0.80
Live M. tuberculosis
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB infection −14.07 (−43.92, 15.79) 0.35 −14.07 (−116.22, 88.08) 0.78
 Pulmonary TB 160.14 (−15.26, 335.53) 0.07 160.14 (−15.87, 336.14) 0.07
 Extrapulmonary TB 16.71 (− 131.40, 164.81) 0.82 −4.05 (− 234.47, 226.38) 0.97
  1. Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
  2. LpqH: 19 kDa lipoprotein of M. tuberculosis; Ref.: reference group; Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method; aAdjusted for foreign-born status
  3. Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)