Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis

Table 3 Median IL-1β production of macrophages assessed 24 h after two hours of stimulation

Factor-by-Group	Interleukin-1β production (in μg/mL)
	Unadjusted difference in median expression			Adjusted difference in median expression^a
	β	95% CI	P-value	β	95% CI	P-value
LpqH
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB infection	−11.95	(−33.51, 9.61)	0.27	−9.62	(−36.41, 17.16)	0.47
Pulmonary TB	−8.95	(−38.11, 20.21)	0.54	−8.95	(−44.03, 26.13)	0.61
Extrapulmonary TB	38.88	(8.45, 69.3)	0.01**	44.99	(−68.86, 158.86)	0.43
Gamma-irradiated M. tuberculosis
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB infection	−44.28	(−88.91, 0.36)	0.05**	−37.92	(−86.66, 10.81)	0.12
Pulmonary TB	−12.89	(−71.47, 45.69)	0.66	− 12.89	(− 101.65, 75.87)	0.77
Extrapulmonary TB	−16.56	(−74.34, 41.23)	0.57	−16.07	(− 143.80, 111.66)	0.80
Live M. tuberculosis
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB infection	−14.07	(−43.92, 15.79)	0.35	−14.07	(−116.22, 88.08)	0.78
Pulmonary TB	160.14	(−15.26, 335.53)	0.07	160.14	(−15.87, 336.14)	0.07
Extrapulmonary TB	16.71	(− 131.40, 164.81)	0.82	−4.05	(− 234.47, 226.38)	0.97

Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
LpqH: 19 kDa lipoprotein of M. tuberculosis; Ref.: reference group; Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method; ^aAdjusted for foreign-born status
Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)

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