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Table 2 Expression of vitamin D receptor (VDR) on macrophages after two hours of macrophage stimulation

From: Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis

Factor-by-Group Vitamin D receptor expression (in relative value units; RVU)
Unadjusted difference in median expression Adjusted difference in median expressiona
β 95% CI P-value β 95% CI P-value
LpqH
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB infection −0.08 (−2.14, 1.99) 0.94 −0.15 (−2.35, 2.05) 0.89
 Pulmonary TB 0.20 (− 0.42, 0.83) 0.52 0.20 (−0.72, 1.13) 0.66
 Extrapulmonary TB −0.43 (−5.34, 4.49) 0.86 −0.63 (−8.29, 7.04) 0.87
Gamma-irradiated M. tuberculosis
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB infection 0.96 (−1.33, 3.26) 0.40 0.48 (−1.79, 2.75) 0.67
 Pulmonary TB 0.48 (−2.61, 3.57) 0.76 0.52 (− 2.15, 3.18) 0.70
 Extrapulmonary TB −1.50 (−5.70, 2.71) 0.48 −1.46 (−6.41, 3.49) 0.56
M. tuberculosis
 Uninfected Ref. Ref.   Ref. Ref.  
 Latent TB Infection −0.04 (−6.44, 6.36) 0.99 −0.09 (−6.47, 6.30) 0.98
 Pulmonary TB 0.93 (−1.04, 2.90) 0.34 0.93 (−1.66, 3.52) 0.47
 Extrapulmonary TB 29.22 (2.36, 56.07) 0.03** 29.17 (5.73, 52.61) 0.02**
  1. Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
  2. LpqH: 19kda lipoprotein of M. tuberculosis; Ref.: reference group
  3. Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method
  4. aAdjusted for foreign-born status. Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)