Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis

Table 2 Expression of vitamin D receptor (VDR) on macrophages after two hours of macrophage stimulation

Factor-by-Group	Vitamin D receptor expression (in relative value units; RVU)
	Unadjusted difference in median expression			Adjusted difference in median expression^a
	β	95% CI	P-value	β	95% CI	P-value
LpqH
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB infection	−0.08	(−2.14, 1.99)	0.94	−0.15	(−2.35, 2.05)	0.89
Pulmonary TB	0.20	(− 0.42, 0.83)	0.52	0.20	(−0.72, 1.13)	0.66
Extrapulmonary TB	−0.43	(−5.34, 4.49)	0.86	−0.63	(−8.29, 7.04)	0.87
Gamma-irradiated M. tuberculosis
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB infection	0.96	(−1.33, 3.26)	0.40	0.48	(−1.79, 2.75)	0.67
Pulmonary TB	0.48	(−2.61, 3.57)	0.76	0.52	(− 2.15, 3.18)	0.70
Extrapulmonary TB	−1.50	(−5.70, 2.71)	0.48	−1.46	(−6.41, 3.49)	0.56
M. tuberculosis
Uninfected	Ref.	Ref.		Ref.	Ref.
Latent TB Infection	−0.04	(−6.44, 6.36)	0.99	−0.09	(−6.47, 6.30)	0.98
Pulmonary TB	0.93	(−1.04, 2.90)	0.34	0.93	(−1.66, 3.52)	0.47
Extrapulmonary TB	29.22	(2.36, 56.07)	0.03**	29.17	(5.73, 52.61)	0.02**

Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
LpqH: 19kda lipoprotein of M. tuberculosis; Ref.: reference group
Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method
^aAdjusted for foreign-born status. Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)

ISSN: 1471-2334