Molecular characterization of enterovirus-A71 in children with acute flaccid paralysis in the Philippines

BMC Infectious Diseases

Table 2 Estimates of Evolutionary Divergence of subgenogroup C2 with EV-A71 Philippine isolates

Case (Location)	EV-A71 strain	JQ621838 JQ621840	JQ621836 JQ621837	JQ621841	JQ621839	JQ621842	JQ621835	MF465901	HM 622392	HQ 676207	HQ 676204	AB 433868
1 (Region XII)	JQ621838 (26/PHL/2000) JQ621840 (27/PHL/2000)	X
2 (Region VIII)	JQ621836 (241/PHL/2002) JQ621837 (255/PHL/2002)	0.044	X
3 (Region IV-A)	JQ621841 (323/PHL/2002)	0.044	0	X
4 (Region IV-A)	JQ621839 (263/PHL/2002)	0.026	0.054	0.054	X
5 (Metro Manila)	JQ621842 (80/PHL/2005)	0.026	0.054	0.054	0.001	X
6 (Metro Manila)	JQ621835 (182/PHL/2005)	0.026	0.054	0.054	0.000	0.001	X
7 (Metro Manila)	MF465901 (S10–217/ PHL/2010)	0.030	0.059	0.024	0.024	0.024	0.024	X
Reference Strain Taiwan	HM622392 (2008–07776)	0.028	0.056	0.056	0.028	0.028	0.028	0.031	X
Reference Strain Japan	HQ676207 (JP28/Sd/W/04)	0.044	0.013	0.013	0.054	0.054	0.054	0.059	0.058	X
Reference Strain Japan	HQ676204 (JP17/Ac/Y/10)	0.032	0.056	0.056	0.031	0.031	0.031	0.037	0.013	0.060	X
Reference Strain Japan	AB433868 (Y97–1055)	0.022	0.032	0.032	0.038	0.038	0.038	0.042	0.040	0.032	0.043	X

X indicates value not calculated because the diagonal values would be homologous comparisons. Data represent number of base substitutions per site from between sequences. Standard error estimate(s) are shown above the diagonal and were obtained by a bootstrap procedure (1000 replicates). Analyses were conducted using the Maximum Composite Likelihood model. All positions containing gaps and missing data were eliminated. Evolutionary analyses were conducted in MEGA7

ISSN: 1471-2334