High incidence and low case detection rate among contacts of tuberculosis cases in Shanghai, China

BMC Infectious Diseases

Table 1 Incidence and correlates of TB disease among 8137 contacts in the Xuhui, Changning, Minhang and Songjiang districts of Shanghai from 2010 to 2014

	No. of contacts	Observed pyrs	No. of TB disease cases	Cumulative incidence /100,000	95% CI	P	Incidence density /100,000 pyrs	Adjusted incidence density /100,000 pyrs^b	95% CI	P
	8137	20,991	69	848	660–1071	–	329	–	–	–
Sex
male	3792	9768	44	1160	844–1555	0.005	450	462	336–616	0.009
female	4345	11,223	25	575	373–848	0.005	223	236	158–350	0.009
Age (years)
1–9	436	1103	2	459	56–1647	0.195	181	184	22–653	0.18
10–19	529	1402	7	1323	534–2707		499	469	201–1026
20–29	1992	5099	25	1255	814–1847		490	490	318–723
30–39	1371	3592	6	438	161–950		167	161	61–363
40–49	1544	4033	16	1036	593–1677		397	402	227–643
50–59	1176	3023	8	680	294–1336		265	272	114–521
60–69	635	1587	2	315	38–1133		126	160	39–551
70–79	309	819	2	647	78–2318		244	450	133–1246
80–89	133	310	1	752	19–4118		323	542	78–2318
≥ 90	12	23	0	0	–		0	0	–
Type of index case
Smear+	5953	16,127	50	840	624–1106	0.892	310	327	246–430	0.217
Smear-	2184	4864	19	870	525–1355	0.892	391	456	284–684	0.217
Bacterial+	7527	19,870	67	890	690–1129	0.172	337	348	270–439	1.000
Bacterial-	610	1121	2	328	40–1179	0.172	178	239	55–780	1.000
Relationship with index case
None-relatives	1175	2915	9	766	351–1449	0.139	309	180	56–400	0.008
Wife/husband	1561	4057	12	769	398–1339		296	283	153–516
Parents/children	2728	7267	30	1100	743–1566		413	487	336–669
Other relatives	2364	5920	13	550	293–939		220	205	105–354
sibling	309	832	5	1618	527–3736		601	567	195–1397
Biologically related family ^a	3037	8099	35	1152	804–1599	0.021	432	475	332,643	0.031
Other relationship	5100	12,892	34	667	462–930	0.021	264	281	196–386	0.031

ISSN: 1471-2334