Incidence and predictors of major adverse drug events among drug-resistant tuberculosis patients on second-line anti-tuberculosis treatment in Amhara regional state public hospitals; Ethiopia: a retrospective cohort study

Table 5 Bi-variable and multi-variable Weibull regression gamma frailty analysis for predictors of major adverse drug events of DR-TB patients on second line anti-TB drugs in Amhara Regional State public hospitals, September 2010 to December 2017

Variables	Event	Censored	CHR (95% CI)	AHR (95% CI)
Age in year
1–24	76	107	1	1
25–49	164	130	2.46 (1.13,5.33)	3.36 (1.36,8.28)^*
> =50	52	41	4.45 (1.47,13.47)	5.60 (1.65,19.05)^*
Comorbid conditions
No	234	252	1	1
Yes^a	58	26	2.19 (1.64,1.92)	2.74 (1.12,6.68)^*
Sex
Male	175	149	1	1
Female	117	129	0.68 (0.34,1.35)	1.02 (0.50,2.06)
Functional status
Working	83	11	1	1
Ambulatory	159	113	2.09 (0.98,4.44)	1.98 (0.91,4.34)
Bed ridden	46	46	3.80 (1.43,10.07)	2.30 (0.78,6.65)
TB complication
No	234	235	1	1
Yes	58	43	1.58 (1.18,2.11)	1.17 (0.46,2.94)
Educational status
Above secondary	82	79	1	1
Primary	86	68	1.24 (0.92,1.68)	1.39 (0.54,3.60)
Not educated	120	129	0.97 (0.74,1.30)	0.50 (0.19,1.30)
Hemoglobin level
Not anemic	179	179	1	1
Anemic	113	99	1.30 (1.03,1.64)	3.25 (1.40,7.53)^*
HIV co-infection
No	86	69	1	1
Yes	206	209	1.27 (0.98,1.63)	0.97 (0.45,2.10)

^*Significant factors at p-value< 0.05
^aDiabetes mellitus, hypertension, chronic obstructive pulmonary diseases, asthma

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