From: Factors associated with the development of Congenital Zika Syndrome: a case-control study
Maternal demographic and gestational variables | Total population (n = 42) | Controls (n = 18) | Cases (n = 24) | P-value |
---|---|---|---|---|
Week of gestation at time of symptoms, median (IQRa) | 13 (8.25–24.25) | 20 | 10 | < 0,01 |
Maternal age at delivery in years, median (IQR) | 21 (19.75–29) | 26.5 | 23 | 0.95 |
Week of gestation at delivery, median (IQR) (missing data: 1) | 38 (37–39) | 39 | 38 | < 0.02 |
Household income per capitab, median (IQR) (missing data: 15) | 0.43 (0.25–0.71) | 0.33 | 0.46 | 0.60 |
No. of previous gestations, median (IQR) | 1 (0–3) | 1 | 2 | 0.89 |
Week of gestation at first prenatal visit, median (IQR) (missing data: 14) | 7 (6–15.25) | 6.5 | 7.5 | 0.96 |
Substance use during pregnancy (%) | ||||
Tobacco | 6/40 (15.00%) | 2/18 (11.11%) | 4/22 (18.18%) | 0.67 |
Alcohol | 10/41 (24.39%) | 4/18 (22.22%) | 6/23 (26.09%) | 1 |
Illicit drugs | 2/40 (5.00%) | 0/18 (0%) | 2/22 (9.09%) | 0.49 |
Maternal coinfections during pregnancyc (%) | ||||
Syphilis | 3/34 (8.10%) | 2/16 (12.50%) | 1/21 (4.76%) | 0.57 |
Human Immunodeficiency Virus | 4/37 (10.81%) | 3/16 (18.75%) | 1/21 (4.76%) | 0.30 |
Maternal dengue virus IgG reactivity at initial evaluation (%) | 9/24 (37.50%) | 5/12 (41.67%) | 4/12 (33.33%) | 1 |