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Table 1 Demographic and Clinical Characteristics of Haematological Malignancy Patients and Haematopoietic Stem Cell Transplantation Recipients, 2005 - 2016

From: A population-based analysis of invasive fungal disease in haematology-oncology patients using data linkage of state-wide registries and administrative databases: 2005 - 2016

Characteristic

Haematological malignancy patients

Haematopoietic stem cell transplantation recipients

Invasive fungal disease cases, N = 669 (%)

Invasive fungal disease controls, N = 32,146 (%)

p-value

Invasive fungal disease cases, N = 111 (%)

Invasive fungal disease controls, N = 1,654 (%)

p-value

Overall crude incidence

669/32,815 = 2.04%

32,146/32,815 = 98%

< 0.001

111/1,765 = 6.29%

1,654/1,765 = 94%

< 0.001

Age (years: median [IQR])

63 [62 – 72]

71 [58 – 81]

< 0.001

54 [41 – 64]

58 [49 – 65]

0.768

 15 – 25

38 (5.7)

899 (2.8)

< 0.001

12 (11)

75 (4.5)

0.011

 26 – 55

187 (28)

6,407 (20)

51 (46)

714 (51)

 56 – 70

189 (29)

7,095 (22)

46 (41)

840 (51)

 71+

179 (27)

15,042 (47)

2 (1.8)

25 (14)

Gender

 Male

406 (60)

18,364 (57)

0.065

63 (57)

1,030 (62)

0.247

Presence of neutropenia

 

549 (82)

6,735 (21)

< 0.001

107 (96)

1,478 (89)

0.018

Inpatient length of stay (LOS; days)

 Median [IQR] hospital LOS

21 [8 – 36]

1 [1 – 1]

< 0.001

32 [25 – 48]

19 [16 – 24]

< 0.001

Intensive Care Unit

 ICU admissions

37 (5.5)

585 (1.8)

< 0.001

0 (0)

4 (0.2)

1.000

 Median [IQR] ICU LOS (days)

6.1 [2.8 – 16]

2.5 [1.1 – 5.3]

< 0.001

0 (0)

4.0 [1.9 – 10]

-

Mechanical ventilation (yes)

29 (4.3)

286 (0.9)

< 0.001

0 (0)

3 (0.2)

1.000

 Median [IQR] ICU mechanical ventilation (days)

6.8 [2.7 – 17]

2.0 [0.6 – 6.0]

< 0.001

-

180 [82 – 280]

 

Haemodialysis

 

68 (10)

478 (1.5)

< 0.001

10 (9.0)

62 (3.8)

0.007

Overall mortality

 One-month

43 (6.4)

1,983 (6.2)

0.783

0 (0)

6 (0.4)

1.000

 Three-month

110 (16)

3,223 (10)

< 0.001

0 (0)

9 (0.54)

1.000

 Six-month

167 (25)

4,353 (14)

< 0.001

4 (3.60)

29 (1.8)

0.149

 Twelve-month

290 (43)

6,004 (19)

< 0.001

20 (18)

108 (6.5)

< 0.001

Hospital region

 Metropolitan Victoria

591 (88)

25,077 (78)

< 0.001

102 (92)

1,388 (84)

0.025

 Regional Victoria

78 (12)

7,069 (22)

9 (8.11)

266 (16)

Charlson Comorbidity Index score ≥ 4

 

192 (27)

3,808 (12)

< 0.001

27 (24)

157 (9.5)

< 0.001

  1. Abbreviations: ICU intensive care unit, IQR inter-quartile range, LOS length of stay