Characteristic | Haematological malignancy patients | Haematopoietic stem cell transplantation recipients | ||||
---|---|---|---|---|---|---|
Invasive fungal disease cases, N = 669 (%) | Invasive fungal disease controls, N = 32,146 (%) | p-value | Invasive fungal disease cases, N = 111 (%) | Invasive fungal disease controls, N = 1,654 (%) | p-value | |
Overall crude incidence | 669/32,815 = 2.04% | 32,146/32,815 = 98% | < 0.001 | 111/1,765 = 6.29% | 1,654/1,765 = 94% | < 0.001 |
Age (years: median [IQR]) | 63 [62 – 72] | 71 [58 – 81] | < 0.001 | 54 [41 – 64] | 58 [49 – 65] | 0.768 |
 15 – 25 | 38 (5.7) | 899 (2.8) | < 0.001 | 12 (11) | 75 (4.5) | 0.011 |
 26 – 55 | 187 (28) | 6,407 (20) | 51 (46) | 714 (51) | ||
 56 – 70 | 189 (29) | 7,095 (22) | 46 (41) | 840 (51) | ||
 71+ | 179 (27) | 15,042 (47) | 2 (1.8) | 25 (14) | ||
Gender | ||||||
 Male | 406 (60) | 18,364 (57) | 0.065 | 63 (57) | 1,030 (62) | 0.247 |
Presence of neutropenia | ||||||
 | 549 (82) | 6,735 (21) | < 0.001 | 107 (96) | 1,478 (89) | 0.018 |
Inpatient length of stay (LOS; days) | ||||||
 Median [IQR] hospital LOS | 21 [8 – 36] | 1 [1 – 1] | < 0.001 | 32 [25 – 48] | 19 [16 – 24] | < 0.001 |
Intensive Care Unit | ||||||
 ICU admissions | 37 (5.5) | 585 (1.8) | < 0.001 | 0 (0) | 4 (0.2) | 1.000 |
 Median [IQR] ICU LOS (days) | 6.1 [2.8 – 16] | 2.5 [1.1 – 5.3] | < 0.001 | 0 (0) | 4.0 [1.9 – 10] | - |
Mechanical ventilation (yes) | 29 (4.3) | 286 (0.9) | < 0.001 | 0 (0) | 3 (0.2) | 1.000 |
 Median [IQR] ICU mechanical ventilation (days) | 6.8 [2.7 – 17] | 2.0 [0.6 – 6.0] | < 0.001 | - | 180 [82 – 280] |  |
Haemodialysis | ||||||
 | 68 (10) | 478 (1.5) | < 0.001 | 10 (9.0) | 62 (3.8) | 0.007 |
Overall mortality | ||||||
 One-month | 43 (6.4) | 1,983 (6.2) | 0.783 | 0 (0) | 6 (0.4) | 1.000 |
 Three-month | 110 (16) | 3,223 (10) | < 0.001 | 0 (0) | 9 (0.54) | 1.000 |
 Six-month | 167 (25) | 4,353 (14) | < 0.001 | 4 (3.60) | 29 (1.8) | 0.149 |
 Twelve-month | 290 (43) | 6,004 (19) | < 0.001 | 20 (18) | 108 (6.5) | < 0.001 |
Hospital region | ||||||
 Metropolitan Victoria | 591 (88) | 25,077 (78) | < 0.001 | 102 (92) | 1,388 (84) | 0.025 |
 Regional Victoria | 78 (12) | 7,069 (22) | 9 (8.11) | 266 (16) | ||
Charlson Comorbidity Index score ≥ 4 | ||||||
 | 192 (27) | 3,808 (12) | < 0.001 | 27 (24) | 157 (9.5) | < 0.001 |