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Table 3 Different MIC and zone diameter breakpoints for cefixime, ceftriaxone, spectinomycin and ciprofloxacin used in the European gonococcal External Quality Assessments (EQAs) from 2007 to 2012

From: Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data

Antimicrobial agent MIC (mg/L) and zone diameter (mm) breakpoints
S ≤ I R >
Cefixime 0.06 ≥0.12
0.12 ≥0.25
0.12a 0.12a
0.25b
≥31c
Ceftriaxone 0.06 ≥0.12
0.12 ≥0.25
0.12a 0.12a
0.25b
≥35c
Spectinomycin 64a 64a
32 32
32b 64b 64b
≥18c 15 – 17c ≤14c
Ciprofloxacin 0.03 0.06 - 0.5 0.5
0.03 0.03
0.03a 0.06a
0.12 0.25
0.06b 0.12 - 0.5a 0.5b
≥41c 28 – 40c ≤27c
  1. Note: Detailed interpretative MIC data was only available until 2012. Adherence to published breakpoints collected post-2012
  2. aCurrent EUCAST breakpoints [17]
  3. bCurrent CLSI breakpoints [16]
  4. cZone diameter breakpoints (mm)