Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors

Table 3 Comparison of concentrations of five cytokines between participants with and without poor prognostic factors (N = 27)

Cytokine/GF protein (pg/mL)	Poor prognostic factors	Low	High	^* P-value
G-CSF	BMI	19.6 (16–42.5)	N/A	NS
min LOD: 16	Alb	54.8 (25.8–70.1)	N/A	NS
max LOD: 10000	CRP	N/A	21.5 (16–66.7)	NS
	Hb	35.6 (16–125.8)	N/A	NS
IL-1RA	BMI	28.2 (10.5–63.9)	17.4 (3.2–24.9)	NS
min LOD: 3.2	Alb	43.2 (22.5–144.4)	19.6 (3.2–30.1)	< 0.05
max LOD 10000	CRP	15.5 (3.2–46.2)	29.1 (17.3–43.2)	NS
	Hb	29.1 (12.9–38.0)	19.6 (3.2–57.5)	NS
IL-10	BMI	1.0 (0.64–4.2)	1.3 (0.64–2.9)	NS
min LOD: 0.64	Alb	2.0 (0.9–18.6)	0.7 (0.64–3.6)	NS
max LOD: 10000	CRP	N/A	1.3 (0.64–4.0)	NS
	Hb	1.3 (0.64–18.6)	0.7 (0.64–2.6)	NS
CXCL10	BMI	953 (429–1568)	359 (226–456)	0.005
min LOD: 3.2	Alb	1030 (774–1816)	449 (274–554)	< 0.005
max LOD: 10000	CRP	445 (263–592)	551 (367–1030)	NS
	Hb	622 (286–1103)	455 (339–593)	NS
sCD40L	BMI	5941 (4235–10,000)	5278 (2808–7197)	NS
min LOD: 0.64	Alb	7611 (4739–10,000)	5317 (3973–8380)	NS
max LOD: 10000	CRP	4866 (3948–6210)	6323 (4300–10,000)	NS
	Hb	5845 (3812–10,000)	5678 (3973–9481)	NS

Data are presented as median (interquartile range). Items with more than half cases below or over the LOD were excluded
Abbreviations, GF growth factor, LOD limit of detection, G-CSF granulocyte colony-stimulating factor, BMI body mass index, Alb albumin, CRP C-reactive protein, Hb hemoglobin, IL-1RA interleukin-1 receptor antagonist, CXCL10 CXC motif ligand 10, sCD40L soluble CD40 ligand, N/A not available (median was below or over LOD)
Definitions: low body mass index: < 20 kg/m²; low albumin: < 3.5 g/dL; high C-reactive protein: > 0.3 mg/dL; Anemia: Hb < 12.0 g/dL in males and < 11.0 g/dL in females
^*P-values were calculated using Wilcoxon rank sum test. If more than half of one group was lower LOD, we used Fisher’s exact test with cut-off as LOD value. NS, not significant

ISSN: 1471-2334