From: Diagnostic accuracy of TB-LAMP for pulmonary tuberculosis: a systematic review and meta-analysis
Reference Standard | Pooled Sensitivity | Pooled Specificity |
---|---|---|
TB-LAMP accuracy if used as an alternative test for smear microscopy in all adults | ||
Standard 1a | 77·7 (71·2–83·0) | 98·1 (95·7–99·2) |
Standard 2a | 76·0 (69·9–81·2) | 98·0 (96·0–99·0) |
Standard 3a | 80·3 (70·3–87·5) | 97·7 (96·1–98·7) |
TB-LAMP accuracy if used as an alternative test for smear microscopy in HIV-positive adults | ||
Standard 1a | N/A (< 4 studies) | N/A (< 4 studies) |
Standard 2a | 63·8 (49·0–76.4) | 98·8 (85·1–99·9) |
Standard 3a | 73·4 (51·9–87·6) | 95·0 (64·0–99·5) |
TB-LAMP accuracy if used as an add-on test in smear-negative adults | ||
Standard 1a | 42·1 (30·0–55·3) | 98·4 (95·9–99·4) |
Standard 2a | 42·2 (27·9–57·9) | 98·0 (96·0–99·0) |
Standard 3a | 40·3 (27·9–54·0) | 97·7 (96·1–98·6) |
TB-LAMP accuracy in studies comparing to Xpertb | ||
Standard 1a | 78·0 (66·6–86·4) | 98·9 (97·4–99·6) |
Standard 2a | 74·1 (64·1–82·2) | 98·8 (96·8–99·6) |
Standard 3a | 75·8 (63·2–85·0) | 98·2 (96·0–99·2) |
Xpert accuracy in studies comparing to TB-LAMPb | ||
Standard 1a | 81·1 (70·6–88·5) | 98·2 (95·9–99·2) |
Standard 2a | 80·4 (73·4–85·9) | 97·4 (94·9–98·7) |
Standard 3a | 84·0 (75·6–90·0) | 97·2 (94·4–98·6) |