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Table 2 Pooled sensitivity and specificity of TB-LAMP

From: Diagnostic accuracy of TB-LAMP for pulmonary tuberculosis: a systematic review and meta-analysis

Reference Standard

Pooled Sensitivity

Pooled Specificity

TB-LAMP accuracy if used as an alternative test for smear microscopy in all adults

 Standard 1a

77·7 (71·2–83·0)

98·1 (95·7–99·2)

 Standard 2a

76·0 (69·9–81·2)

98·0 (96·0–99·0)

 Standard 3a

80·3 (70·3–87·5)

97·7 (96·1–98·7)

TB-LAMP accuracy if used as an alternative test for smear microscopy in HIV-positive adults

 Standard 1a

N/A (< 4 studies)

N/A (< 4 studies)

 Standard 2a

63·8 (49·0–76.4)

98·8 (85·1–99·9)

 Standard 3a

73·4 (51·9–87·6)

95·0 (64·0–99·5)

TB-LAMP accuracy if used as an add-on test in smear-negative adults

 Standard 1a

42·1 (30·0–55·3)

98·4 (95·9–99·4)

 Standard 2a

42·2 (27·9–57·9)

98·0 (96·0–99·0)

 Standard 3a

40·3 (27·9–54·0)

97·7 (96·1–98·6)

TB-LAMP accuracy in studies comparing to Xpertb

 Standard 1a

78·0 (66·6–86·4)

98·9 (97·4–99·6)

 Standard 2a

74·1 (64·1–82·2)

98·8 (96·8–99·6)

 Standard 3a

75·8 (63·2–85·0)

98·2 (96·0–99·2)

Xpert accuracy in studies comparing to TB-LAMPb

 Standard 1a

81·1 (70·6–88·5)

98·2 (95·9–99·2)

 Standard 2a

80·4 (73·4–85·9)

97·4 (94·9–98·7)

 Standard 3a

84·0 (75·6–90·0)

97·2 (94·4–98·6)

  1. aAll reference standards classify patients as having TB if ≥1 positive culture was confirmed as M. tuberculosis by speciation testing. To be classified as not having TB, patients were required to have no positive and at least 1) two negative cultures on two different sputum specimens (Standard 1); 2) two negative cultures on the same or different sputum specimens (Standard 2); or 3) at least one negative culture (Standard 3)
  2. bData restricted to study participants who had valid results for both TB-LAMP and Xpert and testing performed on non-frozen specimens
  3. Abbreviations: N/A not applicable