Skip to main content

Table 3 Comparison of serum cytokines levels of healthy control, severe EV-A71 HFMD before and after treated with IVIG + RBV, and severe EV-A71 HFMD before and after treated with RBV only

From: Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China

Cytokine

(pg/mL)

Control (100)

M (IQR)

IVIG+RBV (28)

M (IQR)

(Before treatment)

IVIG+RBV (28)

M (IQR)

(After treatment)

RBV (62)

M (IQR)

(Before treatment)

RBV (62)

M (IQR)

(After treatment)

χ2

P

IL-1β

3.00(2.95,3.53)a

15.30(8.48,42.70)b

3.25(3.00,3.50)c,a

14.95(8.50,42.35)b

3.45(3.20,3.90)c,a

113.926

< 0.001

IL-2

441.00(350.25,543.25)a

1017.00(726.00,1457.00)b

412.00(312.00,474.00)c,a

1014.50(725.00,1483.25)b

442.00(345.00,527.00)c,a

126.676

< 0.001

IL-6

4.05(3.20,4.70)a

16.00(6.78,82.60)b

4.20(3.60,5.10)c,a

15.95(4.78,85.50)b

4.70(3.70,5.70)c,a

72.654

< 0.001

IL-8

46.00(36.75,52.75)a

225.00(57.70,746.00)b

47.00(38.00,52.00)c,a

178.00(40.70,605.00)b

48.00(40.00,55.00)c,a

47.292

< 0.001

IL-10

5.10(3.68,6.25)a

7.82(6.28,10.20)b

4.50(3.60,6.40)c,a

8.55(6.41,14.85)b

4.10(2.80,6.25)c,a

61.261

< 0.001

IFN-γ

7.00(2.00,11.00)a

47.00(39.00,57.00)b

9.40(7.50,19.50)c,a

39.10(34.00,52.00)b

8.00(7.00,12.00)c,a

25.941

< 0.001

TNF-α

4.65(3.75,5.40)a

25.90(16.53,40.85)b

4.20(3.20,5.00)c,a

25.05(12.75,41.98)b

4.80(3.80,5.30)c,a

145.775

< 0.001

  1. Abbreviations: IVIG intravenous gamma globulin intervention, RBV ribavirin, M median, IQR interquartile range, IL interleukin, IFN interferon, TNF tumor necrosis factor
  2. a vs b, b vs c statistical significance