Challenges and clinical relevance of molecular detection of Bordetella pertussis in South Africa

BMC Infectious Diseases

Table 3 Characteristics of individuals with B. pertussis PCR-positive results that were interviewed following the unusual increase in B. pertussis PCR detection rate in August 2014 (N = 17)

Case	Age group	HIV status	Confirmed/possible pertussis^*	Cough ≥2 weeks	Paroxysmal cough	Inspiratory whoop	Posttussive vomiting	Apnea	Meets clinical case definition^†
1	< 1y	Negative	Possible	No	No	No	No	No	No
2	1-4y	Positive	Confirmed	Yes	Yes	No	No	N/A	Yes
3	25-44y	Positive	Confirmed	No	No	No	No	No	No
4	25-44y	Negative	Confirmed	Yes	Yes	No	No	N/A	Yes
5	25-44y	Positive	Possible	Yes	No	No	No	N/A	No
6	45-64y	Negative	Confirmed	Yes	No	No	No	N/A	No
7	45-64y	Negative	Possible	Yes	No	No	No	N/A	No
8	45-64y	Positive	Possible	Yes	Yes	Yes	No	N/A	Yes
9	1y	Negative	Confirmed	Yes	Yes	No	No	Yes	Yes
10	25-44y	Positive	Confirmed	Yes	Yes	Yes	No	N/A	Yes
11	< 1y	Unknown	Confirmed	Yes	Yes	Yes	Yes	Yes	Yes
12	1-4y	Unknown	Possible	Yes	No	No	No	N/A	No
13	1-4yy	Positive	Possible	Yes	No	No	Yes	N/A	Yes
14	5-14y	Unknown	Possible	Yes	Yes	No	No	N/A	Yes
15	25-44y	Negative	Possible	Yes	No	No	Yes	N/A	Yes
16	25-44y	Negative	Confirmed	Yes	Yes	Yes	No	N/A	Yes
17	5-14y	Unknown	Confirmed	Yes	Yes	Yes	Yes	N/A	Yes

y = age in years. ^*Confirmed case = positive for B. pertussis with IS481 C_t < 35; Possible case = positive for B. pertussis with IS481 35 ≥ C_t ≤ 39. ^†Clinical case definition = cough > 2 weeks (any duration in infants <1 year) + one of the following: paroxysmal cough, inspiratory whoop, posttussive vomiting, apnea in infants < 1 year

ISSN: 1471-2334