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Table 2 Sensitivity and specificity of the PM-TAC assay using ACSF spiked with targeted pathogens

From: Development of a TaqMan Array card to target 21 purulent meningitis-related pathogens

 

Numbers of samples

Targeted Pathogen

IRTP + and PM-TAC +

IRTP + and PM-TAC -

IRTP - and PM-TAC +

IRTP - and PM-TAC -

Streptococcus pneumoniae

18

2

0

10

Streptococcus agalactiae

19

1

0

10

Staphylococcus aureus

20

0

1

9

Listeria monocytogenes

19

1

1

9

Staphylococcus epidermidis

18

2

0

10

Pseudomonas aeruginosa

19

1

2

10

Klebsiella pneumoniae

20

0

0

9

Acinetobacter baumannii

20

0

0

10

Escherichia coli

20

0

0

10

Cryptococcus neoformans

17

3

0

10

Total

Sensitivity = 95%

Specificity = 96%

  1. ACSF artificial cerebrospinal fluid, IRTP Individual Real-time PCR. IRTP was used as the gold standard