Table 1 Clinical-virological characteristics of patients included in the study

Age, years, median (quartile)

25 (24, 26)

29 (25, 33.25)

32 (28.75, 37)

31.5 (26, 38.25)

27 (25.5, 36)

<  0.001

Gender

0.238

Male, n (%)

12 (70.6)

77 (64.2)

17 (85)

55 (76.4)

12 (70.6)

Female, n (%)

5 (29.4)

43 (35.8)

3 (15)

17 (23.6)

5 (29.4)

ALT, U/L, median (quartile)

20.6 (18.3, 22.4)

20.8 (19.1, 22.5)

22.3 (21.6, 23.8)

21.484 (19.8, 23.4)

16 (12.5, 22.0))

< 0.001

Fibroscan, Kpa median (quartile)

4.9 (4.2, 5.4)

5.3 (4.3, 6.5)

4.4 (4.0, 5.3)

4.8 (4.4, 5.4)

4.6 (4.0~5.1)

0.016

HBV DNA, Log IU/ml, median (quartile)

8.2 (8.2, 8.2)

7.7 (5.0, 8.2)

2.2 (1.6, 3.1)

3.3 (2.1, 4.3)

< 0.001

HBeAg status

<  0.001

Negative, n (%)

0 (0)

41 (34)

20 (100)

62 (86)

Positive, n (%)

17 (100)

78 (65)

0 (0)

10 (14)

Missing, n (%)

0 (0)

1 (1)

0 (0)

0 (0)

HBeAb status

<  0.001

Negative, n (%)

17 (100)

70 (58.3)

1 (5)

13 (18.1)

Positive, n (%)

0 (0)

47 (39.2)

19 (95)

59 (81.9)

Missing, n (%)

0 (0)

3 (2.5)

0 (0)

0 (0)

qHBsAg, Log IU/ml, median (quartile)

4.6 (4.5, 4.7)

4.0 (3.3, 4.7)

2.9 (2.0, 3.2)

3.2 (2.3, 3.6)

<  0.001

HBsAb status

<  0.001

Negative, n (%)

15 (88)

106 (88)

20 (100)

67 (93)

Positive, n (%)

2 (12)

14 (12)

0 (0)

5 (7)

HBV genotype

<  0.001

C, n (%)

2 (12)

30 (25)

3 (15)

15 (21)

B, n (%)

12 (71)

74 (62)

8 (40)

27 (38)

Other, n (%)

1 (6)

10 (8)

9 (45)

29 (40)

Missing, n (%)

2 (11)

6 (5)

0 (0)

1 (1)