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Table 6 Dosing of antimicrobials used in the management of intra-abdominal infections in adults with normal renal function

From: The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance

Antimicrobials Dose
β-lactam/β-lactamase inhibitor combination
 AMC 2.2 g IV every 6 h; 2 h infusion timea
 TZP 4.5 g IV every 6 h; 3 h infusion time
 C/T 1.5 g IV every 8 h
 CZA 2.5 g IV every 8 h
Carbapenems
 ETP 1 g IV every 24 h, consider 2 h infusion time
 IPM 1 g IV every 8 h
 MEM 1 g IV every 8 h; consider 2 g IV loading dose; 4 h hour infusion time
Cephalosporins
 CXM 1.5 g IV every 8 h
 CRO 2 g IV every 12–24 h
 CTX 1–2 g IV every 6–8 h
 ZOX 1–2 g IV every 8–12 h
 FEP 2 g IV every 8 h
 CAZ 2 g IV every 8 h
Glycylcyclines
 TGC 100 mg IV loading dose, then 50 mg IV every 12 h
Polymyxin
 Colistimethate sodium 9 million IU IV loading dose, then 4.5 million IU IV q12 h
Aminoglycosides
 GEN 5–7 mg/kg IV every 24 h
 AMK 15–20 mg/kg IV every 24 h
Fluoroquinolones
 CIP 400 mg IV every 8–12 h or 500 mg PO every 8–12 h
 LVX 750 mg every 24 h (IV or PO)
 MOX 400 mg every 24 h (IV or PO)
Metronidazole 500 mg every 8-12 h or 1500 mg every 24 h (IV or PO)
Glycopeptides
 VAN 25–30 mg/kg IV loading dose, then 15–20 mg/kg IV every 8–12 h; target trough 15–20 mg/dL
 TEC 12 mg/kg IV every 12 h for 3 doses (loading dose), then 6–12 mg/kg IV every 24 h
Oxazolidinone
 LZD 600 mg every 12 h (IV or PO)
Azoles
 FLC 800 mg IV loading dose then 400 mg IV every 24 h; 2 h infusion time
Echinocandins
 CAS 70 mg IV loading dose first day, then 50 mg IV daily
 MFG 100 mg daily
 AFG 200 mg loading dose first day, then 100 IV mg daily
  1. KEY: AFG anidulafungin, AMC amoxicillin/clavulanic acid, AMK amikacin, CAS caspofungin, CAZ ceftazidime, CIP ciprofloxacin, CRO ceftriaxone, CTX cefotaxime, CXM cefuroxime, CZA ceftazidime/avibactam, C/T ceftolozane/tazobactam, ETP ertapenem, FEP cefepime, FLC fluconazole, GEN gentamicin, IPM imipenem, IU international units, IV intravenous, LVX levofloxacin, LZD linezolid, MEM meropenem, MFG micafungin, MOX moxifloxacin, PO per os, TEC teicoplanin, TGC tigecycline, TZP piperacillin/tazobactam, VAN vancomycin, ZOX ceftizoxime