Antimicrobials | Dose |
---|---|
β-lactam/β-lactamase inhibitor combination | |
 AMC | 2.2 g IV every 6 h; 2 h infusion timea |
 TZP | 4.5 g IV every 6 h; 3 h infusion time |
 C/T | 1.5 g IV every 8 h |
 CZA | 2.5 g IV every 8 h |
Carbapenems | |
 ETP | 1 g IV every 24 h, consider 2 h infusion time |
 IPM | 1 g IV every 8 h |
 MEM | 1 g IV every 8 h; consider 2 g IV loading dose; 4 h hour infusion time |
Cephalosporins | |
 CXM | 1.5 g IV every 8 h |
 CRO | 2 g IV every 12–24 h |
 CTX | 1–2 g IV every 6–8 h |
 ZOX | 1–2 g IV every 8–12 h |
 FEP | 2 g IV every 8 h |
 CAZ | 2 g IV every 8 h |
Glycylcyclines | |
 TGC | 100 mg IV loading dose, then 50 mg IV every 12 h |
Polymyxin | |
 Colistimethate sodium | 9 million IU IV loading dose, then 4.5 million IU IV q12 h |
Aminoglycosides | |
 GEN | 5–7 mg/kg IV every 24 h |
 AMK | 15–20 mg/kg IV every 24 h |
Fluoroquinolones | |
 CIP | 400 mg IV every 8–12 h or 500 mg PO every 8–12 h |
 LVX | 750 mg every 24 h (IV or PO) |
 MOX | 400 mg every 24 h (IV or PO) |
Metronidazole | 500 mg every 8-12 h or 1500 mg every 24 h (IV or PO) |
Glycopeptides | |
 VAN | 25–30 mg/kg IV loading dose, then 15–20 mg/kg IV every 8–12 h; target trough 15–20 mg/dL |
 TEC | 12 mg/kg IV every 12 h for 3 doses (loading dose), then 6–12 mg/kg IV every 24 h |
Oxazolidinone | |
 LZD | 600 mg every 12 h (IV or PO) |
Azoles | |
 FLC | 800 mg IV loading dose then 400 mg IV every 24 h; 2 h infusion time |
Echinocandins | |
 CAS | 70 mg IV loading dose first day, then 50 mg IV daily |
 MFG | 100 mg daily |
 AFG | 200 mg loading dose first day, then 100 IV mg daily |