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Table 6 Dosing of antimicrobials used in the management of intra-abdominal infections in adults with normal renal function

From: The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance

Antimicrobials

Dose

β-lactam/β-lactamase inhibitor combination

 AMC

2.2 g IV every 6 h; 2 h infusion timea

 TZP

4.5 g IV every 6 h; 3 h infusion time

 C/T

1.5 g IV every 8 h

 CZA

2.5 g IV every 8 h

Carbapenems

 ETP

1 g IV every 24 h, consider 2 h infusion time

 IPM

1 g IV every 8 h

 MEM

1 g IV every 8 h; consider 2 g IV loading dose; 4 h hour infusion time

Cephalosporins

 CXM

1.5 g IV every 8 h

 CRO

2 g IV every 12–24 h

 CTX

1–2 g IV every 6–8 h

 ZOX

1–2 g IV every 8–12 h

 FEP

2 g IV every 8 h

 CAZ

2 g IV every 8 h

Glycylcyclines

 TGC

100 mg IV loading dose, then 50 mg IV every 12 h

Polymyxin

 Colistimethate sodium

9 million IU IV loading dose, then 4.5 million IU IV q12 h

Aminoglycosides

 GEN

5–7 mg/kg IV every 24 h

 AMK

15–20 mg/kg IV every 24 h

Fluoroquinolones

 CIP

400 mg IV every 8–12 h or 500 mg PO every 8–12 h

 LVX

750 mg every 24 h (IV or PO)

 MOX

400 mg every 24 h (IV or PO)

Metronidazole

500 mg every 8-12 h or 1500 mg every 24 h (IV or PO)

Glycopeptides

 VAN

25–30 mg/kg IV loading dose, then 15–20 mg/kg IV every 8–12 h; target trough 15–20 mg/dL

 TEC

12 mg/kg IV every 12 h for 3 doses (loading dose), then 6–12 mg/kg IV every 24 h

Oxazolidinone

 LZD

600 mg every 12 h (IV or PO)

Azoles

 FLC

800 mg IV loading dose then 400 mg IV every 24 h; 2 h infusion time

Echinocandins

 CAS

70 mg IV loading dose first day, then 50 mg IV daily

 MFG

100 mg daily

 AFG

200 mg loading dose first day, then 100 IV mg daily

  1. KEY: AFG anidulafungin, AMC amoxicillin/clavulanic acid, AMK amikacin, CAS caspofungin, CAZ ceftazidime, CIP ciprofloxacin, CRO ceftriaxone, CTX cefotaxime, CXM cefuroxime, CZA ceftazidime/avibactam, C/T ceftolozane/tazobactam, ETP ertapenem, FEP cefepime, FLC fluconazole, GEN gentamicin, IPM imipenem, IU international units, IV intravenous, LVX levofloxacin, LZD linezolid, MEM meropenem, MFG micafungin, MOX moxifloxacin, PO per os, TEC teicoplanin, TGC tigecycline, TZP piperacillin/tazobactam, VAN vancomycin, ZOX ceftizoxime