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Table 2 Projected direct VE calculated in a hypothetical population compared with true and observed direct VE

From: Effects of the rotavirus vaccine program across age groups in the United States: analysis of national claims data, 2001–2016

Direct VE 2010%,
(95% CI)
2011%,
(95% CI)
2012%,
(95% CI)
2013%,
(95% CI)
2014%,
(95% CI)
2015%,
(95% CI)
2016%,
(95% CI)
Truea 95 (90,98) 95 (93, 97) 95 (87, 98) 95 (92, 97) 95 (82, 99) 95 (92, 97) 95 (80, 99)
Observedb 87 (73, 94) 91 (83, 95) 78 (59, 89) 88 (78, 94) 67 (15, 86) 90 (79, 96) 70 (−10, 90)
Projectedc 84 (71, 91) 91 (87, 94) 77 (56, 88) 90 (84, 94) 67 (35, 83) 89 (82, 93) 64 (29, 82)
  1. aTrue VE is a set value used in the calculations
  2. bObserved VE is direct VE estimated using the MarketScan® Commercial Database data
  3. cProjected VE is the direct VE calculated in a hypothetical population of 1,000,000 with vaccine coverage of 50%, true VE of 95%, sensitivity of 0.5, specificity of 0.99, and estimated RVGE incidence among unvaccinated children based on the MarketScan® data for each year from 2010 to 2016