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Table 4 Presence of aminoglycoside-modifying enzyme gene combination in relation to carbapenemase gene content

From: Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance

AME gene(s) Carbapenemase gene bla KPC bla NDM bla VIM bla OXA-48 blaKPC + blaVIM blaNDM + blaOXA-48 blaKPC + blaOXA-48
No (%) of isolates (n = 200) (n = 50) (n = 21) (n = 12) (n = 14) (n = 2) (n = 1)
None 21 (7.0) 19 (9.5)    2 (16.7)    
aac(6΄)-Ib 42 (14.0) 24 (12.0) 17 (34.0)   1 (8.3)    
aac(6′)-Ib + ant(3′)-I 12 (4.0) 9 (4.5)   3 (14.3)     
aac(6΄)-Ib + aph(3΄)-Ia 28 (9.3) 27 (13.5)     1 (7.1)   
aac(6΄)-Ib + aph(3΄)-Ia + ant(3′)-I 86 (28.7) 71 (35.5)   4 (19.0)   11 (78.6)   
aac(3΄)-IIa 3 (1.0)   2 (4.0)   1 (8.3)    
aac(3′)-IIa, ant(3′)-I 2 (0.7)    2 (9.5)     
aac(3′)-IIa, aph(3′)-Ia, ant(3′)-I 1 (0.3)       1 (*)  
aac(6΄)-Ib + aac(3΄)-IIa 32 (10.7) 1 (0.5) 28 (56.0)   2 (16.7)   1 (*)  
aac(6΄)-Ib + aac(3΄)-IIa, ant(3′)-I 5 (1.7) 1 (0.5)    4 (33.3)    
aac(6΄)-Ib + aac(3΄)-IIa + aph(3΄)-Ia 8 (2.7) 5 (2.5) 1 (2.0)   2 (16.7)    
aac(6΄)-Ib + aac(3΄)-IIa + aph(3΄)-Ia, ant(3′)-I 19 (6.3) 17 (8.5)   2 (9.5)     
aph(3΄)-Ia 1 (0.3) 1 (0.5)       
aph(3′)-Ia, ant(3′)-I 2 (0.7) 2 (1.0)       
ant(3′)-I 4 (1.3) 2 (1.0)   1 (4.8)   1 (7.1)   
rmtB + any AME 22 (7.3) 15 (7.5)   6 (28.6)     1 (*)
armA, aac(6′)-Ib, aph(3′)-Ia, ant(3′)-I 1 (0.3) 1 (0.5)       
aac(6′)-Ib + ant(2′)-Ia + ant(3′)-I 1 (0.3)      1 (7.1)   
aac(6′)-Ib + ant(2′)-Ia + aph(3′)-Ia 1 (0.3) 1 (0.5)       
aac(6′)-Ib + aph(3′)-VI 4 (1.3) 3 (1.5) 1 (2.0)      
aac(6′)-Ib + aph(3′)-Ia + aph(3′)-VI 1 (0.3) 1 (0.5)       
aac(6′)-Ib + aph(3′)-VI + ant(3′)-I 1 (0.3)    1 (4.8)     
aac(6′)-Ib + aac(3′)-IIa + aph(3′)-VI 1 (0.3)   1 (2.0)      
aac(6′)-Ib + aac(3′)-IIa + ant(3′)-I+ aph(3′)-Ia + aph(3′)-VI 2 (0.7)    2 (9.5)     
aac(6΄)-Ib ± any other AME/RMT 254 (84.7) 168 (84.0) 48 (96.0) 15 (71.4) 9 (75.0) 13 (92.9) 1 (*)  
aac(3΄)-IIa ± any other AME/RMT 76 (25.3) 26 (13.0) 32 (64.0) 7 (33.3.0) 9 (75.0)   2 (*)  
aph(3΄)-Ia ± any other AME/RMT 167 (55.7) 137 (68.5) 1 (2.0) 14 (66.7) 2 (16.7) 12 (85.7) 1 (*)  
ant(3′)-I ± any other AME/RMT 156 (52.0) 126 (63.0)   21 (100.0) 4 (33.3) 13 (92.9) 1 (*) 1 (*)
aph(3′)-VI ± any other AME/RMT 9 (3.0) 4 (2.0) 2 (4.0) 3 (14.3)     
ant(2′)-Ia ± any other AME/RMT 3 (1.0) 1 (0.5)   1 (4.8)   1 (7.1)   
  1. * % of the isolates was not determined because of the low numbers of isolates