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Table 4 Presence of aminoglycoside-modifying enzyme gene combination in relation to carbapenemase gene content

From: Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance

AME gene(s)

Carbapenemase gene

bla KPC

bla NDM

bla VIM

bla OXA-48

blaKPC + blaVIM

blaNDM + blaOXA-48

blaKPC + blaOXA-48

No (%) of isolates

(n = 200)

(n = 50)

(n = 21)

(n = 12)

(n = 14)

(n = 2)

(n = 1)

None

21 (7.0)

19 (9.5)

  

2 (16.7)

   

aac(6΄)-Ib

42 (14.0)

24 (12.0)

17 (34.0)

 

1 (8.3)

   

aac(6′)-Ib + ant(3′)-I

12 (4.0)

9 (4.5)

 

3 (14.3)

    

aac(6΄)-Ib + aph(3΄)-Ia

28 (9.3)

27 (13.5)

   

1 (7.1)

  

aac(6΄)-Ib + aph(3΄)-Ia + ant(3′)-I

86 (28.7)

71 (35.5)

 

4 (19.0)

 

11 (78.6)

  

aac(3΄)-IIa

3 (1.0)

 

2 (4.0)

 

1 (8.3)

   

aac(3′)-IIa, ant(3′)-I

2 (0.7)

  

2 (9.5)

    

aac(3′)-IIa, aph(3′)-Ia, ant(3′)-I

1 (0.3)

     

1 (*)

 

aac(6΄)-Ib + aac(3΄)-IIa

32 (10.7)

1 (0.5)

28 (56.0)

 

2 (16.7)

 

1 (*)

 

aac(6΄)-Ib + aac(3΄)-IIa, ant(3′)-I

5 (1.7)

1 (0.5)

  

4 (33.3)

   

aac(6΄)-Ib + aac(3΄)-IIa + aph(3΄)-Ia

8 (2.7)

5 (2.5)

1 (2.0)

 

2 (16.7)

   

aac(6΄)-Ib + aac(3΄)-IIa + aph(3΄)-Ia, ant(3′)-I

19 (6.3)

17 (8.5)

 

2 (9.5)

    

aph(3΄)-Ia

1 (0.3)

1 (0.5)

      

aph(3′)-Ia, ant(3′)-I

2 (0.7)

2 (1.0)

      

ant(3′)-I

4 (1.3)

2 (1.0)

 

1 (4.8)

 

1 (7.1)

  

rmtB + any AME

22 (7.3)

15 (7.5)

 

6 (28.6)

   

1 (*)

armA, aac(6′)-Ib, aph(3′)-Ia, ant(3′)-I

1 (0.3)

1 (0.5)

      

aac(6′)-Ib + ant(2′)-Ia + ant(3′)-I

1 (0.3)

    

1 (7.1)

  

aac(6′)-Ib + ant(2′)-Ia + aph(3′)-Ia

1 (0.3)

1 (0.5)

      

aac(6′)-Ib + aph(3′)-VI

4 (1.3)

3 (1.5)

1 (2.0)

     

aac(6′)-Ib + aph(3′)-Ia + aph(3′)-VI

1 (0.3)

1 (0.5)

      

aac(6′)-Ib + aph(3′)-VI + ant(3′)-I

1 (0.3)

  

1 (4.8)

    

aac(6′)-Ib + aac(3′)-IIa + aph(3′)-VI

1 (0.3)

 

1 (2.0)

     

aac(6′)-Ib + aac(3′)-IIa + ant(3′)-I+ aph(3′)-Ia + aph(3′)-VI

2 (0.7)

  

2 (9.5)

    

aac(6΄)-Ib ± any other AME/RMT

254 (84.7)

168 (84.0)

48 (96.0)

15 (71.4)

9 (75.0)

13 (92.9)

1 (*)

 

aac(3΄)-IIa ± any other AME/RMT

76 (25.3)

26 (13.0)

32 (64.0)

7 (33.3.0)

9 (75.0)

 

2 (*)

 

aph(3΄)-Ia ± any other AME/RMT

167 (55.7)

137 (68.5)

1 (2.0)

14 (66.7)

2 (16.7)

12 (85.7)

1 (*)

 

ant(3′)-I ± any other AME/RMT

156 (52.0)

126 (63.0)

 

21 (100.0)

4 (33.3)

13 (92.9)

1 (*)

1 (*)

aph(3′)-VI ± any other AME/RMT

9 (3.0)

4 (2.0)

2 (4.0)

3 (14.3)

    

ant(2′)-Ia ± any other AME/RMT

3 (1.0)

1 (0.5)

 

1 (4.8)

 

1 (7.1)

  
  1. * % of the isolates was not determined because of the low numbers of isolates