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Table 3 MIC and cumulative percent inhibited distributions for plazomicin, in relation to gentamicin and amikacin susceptibility (according EUCAST criteria)

From: Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance

Aminoglycoside susceptibility No of isolates No of isolates / (cumulative % of isolates) inhibited at plazomicin MIC (mg/L) of a
≤0.125 0.25 0.5 1 2 4 8 16 32 ≥64d
Amikacin Sb 54 5
(9.3)
23
(51.9)
11
(72.2)
9
(88.9)
1
(90.7)
5
(100)
0
(−)
0
(−)
0
(−)
0
(−)
Amikacin NSc 246 3
(1.2)
55
(23.6)
56
(46.3)
74
(76.4)
24
(86.2)
8
(89.4)
3
(90.7)
0
(90.7)
0
(90.7)
23
(100)
Amikacin NS (excluding RMT positive isolates) 223 3
(1.3)
55
(26.0)
56
(51.1)
74
(84.3)
24
(95.1)
8
(98.7)
3
(100)
0
(−)
0
(−)
0
(−)
Gentamicin S 129 3
(2.3)
52
(42.6)
41
(74.4)
24
(93.0)
5
(96.9)
4
(100)
0
(−)
0
(−)
0
(−)
0
(−)
Gentamicin NS 171 5
(2.9)
26
(18.1)
26
(33.3)
59
(67.8)
20
(79.5)
9
(84.8)
3
(86.5)
0
(86.5)
0
(86.5)
23
(100)
Gentamicin NS (excluding RMT positive isolates) 148 5
(3.4)
26
(20.9)
26
(38.5)
59
(78.4)
20
(91.9)
9
(97.8)
3
(100)
0
(−)
0
(−)
0
(−)
Amikacin NS/Gentamicin NS 154 2
(1.3)
15
(11.0)
25
(27.3)
58
(64.9)
20
(77.9)
8
(83.1)
3
(85.1)
0
(85.1)
0
(85.1)
23
(100)
Amikacin NS/Gentamicin NS (excluding RMT positive isolates) 131 2
(1.5)
15
(13.0)
25
(32.1)
58
(76.3)
20
(91.6)
8
(97.7)
3
(100)
0
(−)
0
(−)
0
(−)
Amikacin NS/Gentamicin S 92 1
(1.1)
40
(44.6)
31
(78.3)
16
(95.7)
4
(100)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
Amikacin S/Gentamicin NS 17 3
(17.6)
11
(82.4)
1
(88.2)
1
(94.1)
0
(94.1)
1
(100)
0
(−)
0
(−)
0
(−)
0
(−)
Amikacin S/Gentamicin S 28 1
(3.6)
8
(32.1)
6
(53.6)
8
(82.1)
1
(85.7)
4
(100)
0
(−)
0
(−)
0
(−)
0
(−)
All isolates excluding RMT positives 277 8
(2.9)
78
(31.0)
67
(55.2)
83
(85.2)
25
(94.2)
13
(98.9)
3
(100)
0
(−)
0
(−)
0
(−)
  1. a The MIC inhibiting 90% of isolates (MIC90) is bolded
  2. b S; susceptible
  3. c NS; non susceptible
  4. d All isolates (n = 23) with plazomicin MIC ≥64 mg/L harbored a 16S rRNA methylase gene