Skip to main content

Table 2 Performance of different analytes used to discriminate between latent and active tuberculosis

From: Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak

Biomarker AUC Sensitivity Specificity PPV NPV LR+ LR-
Plasma IL-15 < 167.6 pg/mL 0.7769 65.2% 82.6% 78.9 70.3 3.75 0.42
IL-15nil < 137.2 pg/mL 0.9509 90.9% 88.0% 88.3 90.6 7.58 0.1
IL-15TB < 174.2 pg/mL 0.6927 63.6% 80.0% 76.1 68.7 3.18 0.45
IL-32nil ≥ 662.3 pg/mL 0.8109 86.4% 76.0% 78.3 84.8 3.6 0.18
IL-32TB ≥ 627.6 pg/mL 0.9491 90.9% 92.0% 91.8 90.9 11.36 0.1
Vitamin D < 12.05 ng/mL 0.6843 39.1% 91.3% 81.8 60 4.49 0.67
IL-15nil < 137.2 pg/mL or IL-32TB ≥ 627.6 pg/mL 0.964 100% 82.6% 85.2 100 5.75 0
  1. ROC curves were drawn
  2. ROC: receiver operating characteristic; AUC: area under the curve
  3. PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio-positive; LR−, likelihood ratio-negative