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Table 2 Fluoroquinolone resistance-associated mutations and corresponding amino acid changes in Mycoplasma genitalium, Gauteng Province, South Africa

From: Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Johannesburg, South Africa, 2007–2014

Gene Mutation/s Amino acid change/s No. of samples (n = 266) Frequency (%) Associated with clinically-relevant antimicrobial resistance
Yes/No/ Unknown Reference
gyrA G207A M69I 2 0.8 Unknown N/A
G231A No change 1 0.4 N/A N/A
A288G No change 2 0.8 N/A N/A
A318G No change 1 0.4 N/A N/A
C321T No change 1 0.4 N/A N/A
T348C No change 1 0.4 N/A N/A
A353G H118R 1 0.4 Unknown N/A
parC C234T No change 1 0.4 N/A N/A
G259 T D87Y 1 0.4 Yes [29, 35, 50, 52]
G291A No change 1 0.4 N/A N/A
A338G D113G 1 0.4 Unknown N/A
C184T + C234T P62S 50 18.8 Unknown [35, 46, 54]
C184T + C234T + A338G P62S + D113G 1 0.4 Unknown N/A
  1. N/A Not applicable