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Table 2 Clinical symptom and sign at the initial presentation (n = 362)

From: Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction

Variable

Scrub typhus (n = 255)

SFTS

P valuec

Eschar-positive

P valuea

Eschar-negative

P valueb

n = 107

n = 205

n = 50

Fever

205 (100)

< 0.001

50 (100)

0.017

95/106 (89.6)

< 0.001

Headache

179 (87.3)

< 0.001

30 (60.0)

< 0.001

26/105 (24.8)

< 0.001

Myalgia

172 (83.9)

< 0.001

29 (58.0)

0.794

58/104 (55.8)

< 0.001

Conjunctival injection

78 (38.0)

< 0.001

6 (12.0)

0.215

6/98 (6.1)

< 0.001

Sore throat

74 (36.1)

< 0.001

11 (22.0)

0.005

7/105 (6.7)

< 0.001

Cough

76 (37.1)

< 0.001

15 (30.0)

0.004

12/105 (11.4)

< 0.001

Dyspnea

47 (22.9)

0.004

9 (18.0)

0.138

10/104 (9.6)

0.006

Nausea/vomiting

81 (39.5)

0.463

14 (28.0)

0.370

37/105 (35.2)

0.718

Abdominal pain

58 (28.3)

0.019

9 (18.0)

0.778

17/105 (16.2)

0.033

Arthralgia

62 (30.2)

< 0.001

4 (8.0)

0.429

5/104 (4.8)

< 0.001

Skin rash

180 (87.8)

< 0.001

39 (78.0)

< 0.001

6/105 (5.7)

< 0.001

Presence of bite wound

205 (100)

< 0.001

0 (0)

< 0.001

30/106 (28.3)

< 0.001

Altered mentality

11 (5.4)

< 0.001

5 (10.0)

0.012

29/104 (27.9)

< 0.001

Shock (MAP < 65 mmHg)

15 (7.3)

0.085

4 (8.0)

0.427

14/105 (13.3)

0.079

  1. Abbreviations: SFTS severe fever with thrombocytopenia syndrome, MAP mean arterial pressure
  2. aP value when compared to SFTS
  3. bP value when compared to SFTS
  4. cP value when compared to all scrub typhus