|
ICU admission
|
58 (64)
|
67 (21)
|
< 0.0001
|
|
ICU admission within 48 h of first positive culture
|
51 (57)
|
50 (16)
|
< 0.0001
|
|
Need for vasopressors
|
31 (35)
|
17 (6)
|
< 0.0001
|
|
Duration of ICU stay, daysa
|
5 (2, 12.3)
|
3 (1, 7)
|
0.01
|
|
Duration of ICU stay > 72 h
|
43 (48)
|
38 (12)
|
< 0.0001
|
|
Day 4 Success
|
45 (50)
|
228 (73)
|
< 0.0001
|
|
Died
|
2 (4)
|
2 (1)
|
0.07
|
|
Day 4 Failure
|
44 (49)
|
83 (27)
|
< 0.0001
|
|
Died
|
15 (34)
|
7 (8)
|
0.0003
|
|
Microbial Persistence on day 4
|
31 (34)
|
62 (20)
|
0.0039
|
|
Died
|
10 (32)
|
3 (5)
|
0.0007
|
|
Initial GCS < 15
|
54/89 (61)
|
31/306 (10)
|
< 0.0001
|
|
Died
|
13 (24)
|
2 (6)
|
0.04
|
|
Initial SBP ≤ 100 mmHg
|
57/84 (68)
|
52/297 (18)
|
< 0.0001
|
|
Died
|
12 (21)
|
3 (6%)
|
0.026
|
|
Initial RR ≥ 22 breaths per minute
|
72/85 (85)
|
71/298 (24)
|
< 0.0001
|
|
Died
|
14 (19)
|
4 (6)
|
0.021
|
|
30-day mortality
|
17 (19)
|
9 (3)
|
< 0.0001
|
|
Total Hospital LOS, days a
|
16 (8, 32)
|
10 (6, 19)
|
< 0.0001
|
|
LOS after first positive culture, days a
|
14 (7.8, 23)
|
9 (6.25, 17)
|
0.001
|
|
Disposition of survivors
|
N = 73
|
N = 303
|
0.92
|
|
Home
|
48 (66)
|
198 (65)
| |
|
Skilled nursing facility
|
12 (16)
|
47 (16)
| |
|
Outside Hospital
|
4 (5)
|
23 (8)
| |
|
Rehab center
|
7 (10)
|
23 (8)
| |
|
Homeless/jail
|
2 (3)
|
12 (4)
| |
