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Table 3 Estimation of diagnostic validity of LF-RPA assay with 114 CSF specimens

From: Development of a lateral flow recombinase polymerase amplification assay for rapid and visual detection of Cryptococcus neoformans/C. gattii in cerebral spinal fluid

  Culture/India ink staining Performance characteristics (%)
Positive Negative Se Sp PPV NPV
LF-RPA Pos 40 3 95.2a 95.8b 93.0c 97.2d
Neg 2 69
CrAg Lateral Flow Assay Pos 42 0 100e 100f 100 100
Neg 0 72
  1. Pos: positive; Neg: negative; Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval.
  2. a 95% CI: 83.84%-99.42%; b 95% CI: 88.30%-99.13%; c 95% CI: 81.46%-97.59%; d 95% CI: 89.91%-99.26%; e 95% CI: 91.59%-100.00%; f 95% CI: 95.01%-100.00%.