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Table 1 Clinical characteristics of participants

From: Immune signatures for HIV-1 and HIV-2 induced CD4+T cell dysregulation in an Indian cohort

 

HIV-1

HIV-2

Seronegative

 

ART-naïve

ART- receivingd

ART-naïve

ART- receivingd

Number of participants

24

19

16

19

33

Agea (Years)

39 (18–57)

41.50 (30–50)

46 (23–55)

45.5 (20–59)

30 (21–55)

CD4 Cell Counta (Cells/ul)

554 (210–990)

625 (372–1508)

813b (504-1641)

441c (158-1107)

NA

Viremiaa (RNA Copies/ml)

14,199 (203–400,644)

< 34

NA

NA

NA

Duration between diagnosis and samplinga (Years)

1.4 (0.8–3.5)

4 (2–6)

1 (0.5–3)

3 (1–7)

–

  1. aData are expressed as the median (range)
  2. bAbsolute CD4 count for ART-naïve HIV-2 infected individuals was significantly higher than that for HIV-1 infected participants (unpaired t-test with Welch’s correction; p < 0.01)
  3. cAbsolute CD4 count for ART-naïve HIV-2 infected individuals was significantly higher than that for ART-treated HIV-2 infected participants (unpaired t-test with Welch’s correction; p < 0.01)
  4. NA not applicable
  5. dART regimen for HIV-1 infected individuals was Zidovudine (AZT) + Lamivudine (3TC) + Nevirapine (NVP) and regimen for HIV-2 infected individuals was Zidovudine (AZT) + Lamivudine (3TC) + Lopinavir /Ritonavir (LPV)
  6. All individuals that were included in ART receiving groups of either infection were on ART for at least 1 year. For HIV-1 infected individuals, range with median duration was (1–3) 1.8 years and for HIV-2 infected individuals, range with median duration was (1–3) 2 years