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Table 3 Rate ratio (RR) of excess mortality or hospitalization associated with influenza between the post-SARS and pre-SARS (reference) periods in Hong Kong and Brisbane; and the ratio of RR (RRR) between Hong Kong (HK) and Brisbane

From: Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination

 

Whole period

Peak seasons onlyaPeak seasons onlya

Vaccine matched years onlybVaccine matched years onlyb

Hong Kong

Brisbane

Hong Kong

Brisbane

Hong Kong

Brisbane

 

RR

95% CI

RR

95% CI

RR

95% CI

RR

95% CI

RR

95% CI

RR

95% CI

Mortality Post-SARS vs Pre-SARS

 All-causes

1.22

(1.10,1.35)

0.87

(0.62,1.21)

1.48

(1.35,1.63)

0.93

(0.72,1.19)

2.62

(2.25,3.05)

4.39

(2.67,7.22)

 CRD

0.90

(0.80,1.01)

0.79

(0.54,1.15)

1.11

(1.00,1.23)

3.54

(2.23,5.62)

1.25

(1.08,1.45)

4.75

(2.55,8.83)

 P&I

2.50

(2.00,3.13)

NE

 

1.26

(1.06,1.49)

NE

 

1.53

(1.23,1.91)

NE

 

 COPD

1.04

(0.78,1.38)

1.03

(0.44,2.39)

NE

 

1.71

(0.54,5.37)

NE

 

1.39

(0.62,3.13)

 Stroke

0.74

(0.50,1.09)

0.33

(0.13,0.80)

NE

 

0.31

(0.14,0.71)

1.18

(0.81,1.71)

0.58

(0.28,1.20)

 IHD

0.45

(0.34,0.58)

1.09

(0.62,1.90)

0.48

(0.40,0.58)

1.36

(0.81,2.27)

0.16

(0.11,0.23)

NE

 

Hospitalization Post-SARS vs Pre-SARS

 CRD

0.86

(0.82,0.91)

26.82

(9.56,75.24)

5.25

(4.86,5.68)

NE

 

15.83

(13.50,18.56)

28.09

(9.80,80.53)

 P&I

2.79

(2.57,3.03)

3.49

(1.96,6.21)

5.18

(4.74,5.67)

NE

 

6.37

(5.65,7.19)

2.02

(1.20,3.40)

 COPD

1.04

(0.96,1.14)

1.33

(0.91,1.93)

9.12

(7.77,10.71)

1.35

(0.96,1.89)

NE

 

1.10

(0.76,1.59)

 Stroke

0.15

(0.12,0.19)

NE

 

0.02

(0.01,0.05)

NE

 

NE

 

NE

 

 IHD

NE

 

NE

 

NE

 

NE

 

NE

 

NE

 

Mortality Post-pandemic vs Pre-SARS

 All-causes

1.41

(1.28,1.56)

2.39

(1.83,3.12)

1.16

(1.06,1.28)

2.06

(1.67,2.55)

2.96

(2.55,3.44)

7.21

(4.48,11.62)

 CRD

1.16

(1.04,1.29)

0.98

(0.69,1.38)

1.06

(0.96,1.18)

4.10

(2.61,6.44)

1.48

(1.29,1.71)

2.19

(1.12,4.27)

 P&I

2.44

(1.95,3.05)

NE

 

1.51

(1.28,1.77)

NE

 

1.69

(1.37,2.09)

NE

 

 COPD

1.07

(0.81,1.41)

1.75

(0.83,3.67)

NE

 

7.42

(2.82,19.54)

NE

 

1.86

(0.87,3.96)

 Stroke

1.26

(0.90,1.77)

0.29

(0.12,0.72)

NE

 

0.77

(0.42,1.39)

1.43

(1.01,2.03)

0.43

(0.20,0.93)

 IHD

0.74

(0.59,0.92)

NE

 

0.34

(0.27,0.41)

NE

 

0.40

(0.31,0.51)

NE

 
  1. Note: NE, not estimated due to negative estimates in annual excess rates.The p-value of the RRR of Hong Kong versus Brisbane was calculated from z-tests
  2. a Influenza peak season is January to July in Hong Kong, May to November in Brisbane
  3. b The data of years 2003, 2004 and 2008 were excluded due to mismatch between vaccine composite and circulating influenza strains