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Table 1 Meta-analysis of the studies that compare the odds of placental P. falciparum infection among individuals with blood group A, B, AB or non-O vs those with blood type O

From: Effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum infection: systematic review and meta-analysis

      Odds of Placental malaria (95% CI)
Parity Placental malaria Type Study Sample size A vs O B vs O AB vs O Non-O vs O
Primiparae or Multiparae Active or passive vs none Adam et al. 2007 293 0.8 (0.44, 1.44) 0.55 (0.27, 1.1) 0.57 (0.21, 1.55) 0.67 (0.41, 1.1)
Loscertales & Brabin, 2006 198 1.35 (0.63, 2.91) 1.17 (0.59, 2.29) 1.58 (0.28, 9.01) 1.26 (0.71, 2.22)
Senga et al. 2007 647 1.32 (0.89, 1.96) 1.22 (0.83, 1.79) 3.68 (1.39, 9.74) 1.35 (0.99, 1.85)
Bedu-Addo et al. 2014 827 1.16 (0.81, 1.66) 1.62 (1.09, 2.39) 1.77 (0.8, 3.91) 1.38 (1.04, 1.85)
Adegnika et al. 2011 378 1.11 (0.39, 3.19) 2.38 (0.91, 6.23) 2.00 (0.23, 17.13) 1.64 (0.75, 3.59)
Ukaga et al. 2007 586 0.72 (0.46, 1.13) 0.68 (0.39, 1.18) 0.21 (0.07, 0.62) 0.61 (0.42, 0.89)
Adam et al. 2009 236 1.25 (0.91, 2.5)
Alim et al. 2015 126 1.11 (0.4, 3.33)
summary OR (95% CI)   0.97 (0.75, 1.19) I2 = 8.2%, p = 0.007 1.02 (0.64, 1.40) I2 = 58.0%, p = 0.036 0.59 (0.02, 1.14)
I2 = 32.9%, p = 0.189
1.01 (0.73, 1.29) I2 = 58.8%, p = 0.017
Primiparae Active vs uninfected Adam et al. 2007 293 2/31 vs 0/51 0/24 vs 0/51 1/8 vs 0/51 3/50 vs 0/51
Loscertales & Brabin, 2006 198 0.55 (0.15, 1.99) 0.33 (0.10, 1.08) 0.41 (0.16, 1.08)
Senga et al. 2007 647 0.31 (0.10, 0.97) 0.79 (0.30, 2.06) 0.93 (0.06, 15.62) 0.54 (0.24, 1.21)
Bedu-Addo et al. 2014 827 2.59 (1.03, 6.50) 1.56 (0.84, 2.91) 4.53 (0.52, 39.74) 1.90 (1.10, 3.28)
Adegnika et al. 2011 378 4.8 (0.73, 31.48) 1.85 (0.16, 2.2) - 3.2 (0.55, 18.56)
summary OR (95% CI)   0.41 (0.003, 0.82) I2 = 1.4%, p = 0.385 1.04 (0.3, 1.78)
I2 = 68.9%, p = 0.022
1.42 (−5.81, 8.65)
I2 = 0.0%, p = 0.738
0.75 (0.17, 1.34) I2 = 53.8%, p = 0.090
Passive vs uninfected Adam et al. 2007 293 0.46 (0.15, 1.41) 0.31 (0.08, 1.20) 0.87 (0.15, 5.00) 0.44 (0.18, 1.08)
Loscertales & Brabin, 2006 198 2.13 (0.42, 10.73) 1.28 (0.28, 5.93) 2.00 (0.55, 7.18)
Senga et al. 2007 647 1.28 (0.58, 2.81) 1.24 (0.54, 2.83) 2.48 (0.26, 23.38) 1.32 (0.67, 2.52)
Bedu-Addo et al. 2014 827 2.23 (1.17, 4.26)
summary OR (95% CI)   0.68 (0.13, 1.22) I2 = 0.0%, p = 0.390 0.59 (0.03 1.21) I2 = 14.4%, p = 0.331 0.94 (0.44, 3.31) I2 = 0.0%, p = 0.789 0.82 (0.08, 1.57) I2 = 42.5%, p = 0.176
Active vs passive Loscertales & Brabin, 2006 198 0.26 (0.05, 1.26) 0.63 (0.27, 1.49) 0.38 (0.04, 3.53) 0.42 (0.2, 0.86)
Senga et al. 2007 647 0.24 (0.08, 0.70) 0.69 (0.31, 1.53) 0.49 (0.05, 4.34) 0.46 (0.23, 0.92)
Bedu-Addo et al. 2014 827 1.44 (0.56, 3.69)
summary OR (95% CI)   0.24 (0.03, 0.52),
I2 = 0.0%, p = 0.954
0.66 (0.23, 1.09), I2 = 0.0%, p = 0.892 0.42 (0.01, 1.78),
I2 = 0.0%, p = 0.938
0.46 (0.23, 0.69)
I2 = 0.0%, p = 0.458
Multiparae Active vs uninfected Adam et al. 2007 293 3.59 (0.66, 19. 69) 2 (0.26, 15.12) 2.37 (0.47, 11.91)
Loscertales & Brabin, 2006 198 1.55 (0.45, 5.34) 2.07 (0.72, 5.93) 2.07 (0.26, 16.27)) 1.87 (0.77, 4.56)
Senga et al. 2007 647 1.78 (0.95, 3.35) 1.54 (0.84, 2.86) 5.27 (1.44, 19.32) 1.78 (1.07, 2.96)
Bedu-Addo et al. 2014 827 0.21 (0.11, 0.40) 0.36 (0.19, 0.66) 0.36 (0.12, 1.07) 0.29 (0.17, 0.48)
Adegnika et al. 2011 378 0.51 (0.11, 2.37) 2.59 (0.91, 7.37) 2.44 (0.27, 21.98) 1.36 (0.55, 3.34)
summary OR (95% CI)   0.76 (0.02, 1.54) I2 = 51.7%, p = 0.082 1.11 (0.15, 2.07) I2 = 52.2%, p = 0.079 0.38 (0.09, 0.86) I2 = 0.0%, p = 0.515 1.20 (0.22, 2.19) I2 = 72.1%, p = 0.006
Passive vs uninfected Adam et al. 2007 293 0.56 (0.19, 1.66) 0.99 (0.37, 2.62) 0.47 (0.10, 1.94) 0.70 (0.32, 1.53)
Loscertales & Brabin, 2006 198 3.22 (0.94, 11.05) 2.93 (0.94, 9.13) 2.76 (1.04, 7.34)
Senga et al. 2007 647 1.22 (0.58, 2.58) 1.18 (0.58, 2.39) 6.32 (1.71, 23.41) 1.38 (0.78, 2.45)
summary OR (95% CI)   0.82 (0.24, 1.41) I2 = 0.0%, p = 0.375 1.16 (0.46, 1.85) I2 = 0.0%, p = 0.668 1.01 (0.001, 2.77)
I2 = 16.1%, p = 0.304
1.06 (0.38, 1.74) I2 = 31.8%, p = 0.231
Active vs passive Loscertales & Brabin, 2006 198 1.46 (0.6, 3.54) 0.71 (0.21, 2.34) 0.68 (0.24, 1.95)
Senga et al. 2007 647 1.46 (0.6, 3.54) 1.31 (0.56, 3.08) 1.29 (0.64, 2.59)
Adam et al. 2007 293 5.18 (0.76, 21.87) 2.9 (0.36, 26.39) 1.21 (0.16, 9.23)
summary OR (95% CI)   1.49 (0.46, 2.53) I2 = 0.0%, p = 0.790 0.97 (0.16, 1.78) I2 = 0.0%, p = 0.743 0.95 (0.31, 1.59) I2 = 0.0%, p = 0.650
  1. Summary OR estimated using a meta-analysis technique applying fixed (I2 < 30%) or random (I2 ≥ 30%) effect model. Statistical significance of the heterogeneity of the studies was tested using the Cochran’s Q test at α = 5%