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Table 1 Results of investigation performed for primary biliary cirrhosis and liver transplant workup

From: Pneumocystis jirovecii-related spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in a liver transplant recipient: a case report

Test performed Results (Reference range)
Pre-transplant
 Hepatitis serology
  HBsAg Negative
  Anti-HBs <  10 mlU/mL
  Anti-HBc (total) Negative
  Anti-HAV (total) Positive
  Anti-HAV IgM Negative
 Autoimmune markers
  C3 135 (76–150) mg/dL
  C4 26 (9–35) mg/dL
  ANA titre Could not be interpreted due to cytoplasmic staining
  Anti-ds DNA 7 (0–35) IU/ml
  Anti-smooth muscle Ab Negative
  Anti-mitochrondrial Ab Positive, M2 pattern
 Immunoglobulin (Ig) pattern
  IgG 3540 (819–1725) mg/dL
  IgA 407 (70–386) mg/dL
  IgM 474 (55–307) mg/dL
 Lung function test
  Forced vital capacity (FVC) 2.23 L, 96%
  Forced expiratory volume during the 1 sec/FVC (FEV1/FVC) 70% predicted
 liver biopsy – hepatectomy Primary biliary cirrhosis with impending cirrhosis
This admission
 Blood culture No growth
 Nasopharyngeal aspirate Polymerase chain reaction (PCR) positive for Respiratory syncytial virus (RSV) and Enterovirus(EV)/ Rhinovirus (RV)
Negative for Influenza A virus, Influenza B virus, Parainfluenza virus, Adenovirus, human metapneumovirus
 Sputum culture Candida albicans
 Mid-stream/Catheterized urine culture No growth
 Serum Cryptococcal antigen Negative
 Plasma CMV pp65 Antigen Negative
Bronchoalveolar lavage fluid
- Gram stain No organism seen
- Bacterial culture Candida species
- Acid fast bacilli (AFB) smear and culture Negative and no growth of AFB
- Fungal smear / culture Smear negative / Candida albicans
- TB-PCR Negative
- Pneumocystis jirovecii qualitative PCR Positive
- CMV qualitative PCR Positive
- Respiratory viruses antigen detection by immunofluorescence Positive for RSV
- Respiratory viruses qualitative PCR Positive for RSV
Negative for EV/RV, Influenza A virus, Influenza B virus, Parainfluenza virus, adenovirus, human metapneumovirus
Liver biopsy (28 months post-transplant) Non-specific change
  1. Ab antibody, ANA anti-nuclear antibody, Anti-Hbc antibody to hepatitis B core antigen, CMV cytomegalovirus, ds double-stranded, HAV hepatitis A virus, HBsAg hepatitis B surface antigen, IgM immunoglobulin M, NA not available, TB tuberculosis