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Table 5 Logistic regression analysis of risk factors for unsuccessful treatment outcomes at the study site (n = 508)
| Variables | Treatment outcomes | Univariate analysis | P value* | Multivariate analysis | P value* | |
|---|---|---|---|---|---|---|
| Successful n (%) | Unsuccessful n (%) | COR (95% CI) | AOR (95% CI) | |||
| Gender | ||||||
| Male | 230 (95.8) | 10 (4.2) | 1 | 0.485 | – | – |
| Female | 253 (94.4) | 15 (5.6) | 1.364 (0.60–3.09) | |||
| Age (years) | ||||||
| ≤ 2 | 167 (96) | 7 (4) | 1 | 0.501 | – | – |
| 3–5 | 118 (98.3) | 2 (1.7) | 0.269 (0.06–1.15) | 0.078 | – | – |
| 6–10 | 132 (95) | 7 (5) | 1.034 (0.42–2.53) | 0.942 | – | – |
| 11–14 | 66 (88) | 9 (12) | 3.554 (1.50–8.37) | 0.004 | 2.908 (0.78–10.77) | 0.110 |
| Residence | ||||||
| Rural | 192 (93.2) | 14 (6.8) | 1.929 (0.85–4.33) | 0.112 | – | – |
| Urban | 291 (96.4) | 11 (3.6) | 1 | |||
| Type of TB | ||||||
| PTB+ | 20 (69) | 9 (31) | 13.022 (5.13–33.04) | < 0.001 | 5.910 (1.64–21.29) | 0.007 |
| PTB- | 48 (92.3) | 4 (7.7) | 1.726 (0.56–5.23) | 0.335 | – | – |
| PTBNS | 308 (97.8) | 7 (2.2) | 0.221 (0.09–0.53) | 0.001 | 0.771 (0.24–2.43) | 0.657 |
| EPTB | 107 (95.5) | 5 (4.5) | 1 | 0.800 | – | – |
| Weight(percentiles) | ||||||
| Underweight | 46 (90.2) | 5 (9.8) | 2.375 (0.85–6.62) | 0.098 | – | – |
| Normal | 437 (95.6) | 20 (4.4) | 1 | |||
| Registration category at baseline | ||||||
| New | 465 (95.9) | 20 (4.1) | 1 | 0.001 | 0.368 (0.08–1.56) | 0.176 |
| Retreated | 18 (78.3) | 5 (21.7) | 6.458 (2.17–19.15) | 2.720 (0.63–11.59) | ||
| ADRs | ||||||
| Yes | 53(79) | 14 (21) | 10.326 (4.45–23.91) | < 0.001 | 11.601 (4.06–33.12) | < 0.001 |
| No | 430 (97.5) | 11 (2.5) | 1 | 0.086 (0.03–0.24) | ||
| BCG scar | ||||||
| Present | 412 (94.5) | 24 (5.5) | 1 | 0.168 | – | – |
| Absent | 71 (98.6) | 1 (1.4) | 0.242 (0.03–1.81) | |||
| Baseline X-ray | ||||||
| Normal | 125 (95.4) | 6 (4.6) | 1 | 0.834 | ||
| Abnormal | 300 (94.3) | 18 (5.7) | 1.569 (0.64–3.82) | 0.323 | – | – |
| Not done | 58 (98.3) | 1 (1.7) | 0.305 (0.04–2.30) | 0.249 | ||
| TST | ||||||
| Positive (≥ 10 mm) | 259 (96.6) | 9 (3.4) | 1 | 0.091 | – | – |
| Negative (< 10 mm) | 224 (93.3) | 16 (6.7) | 2.056 (0.89–4.74) | |||
| HHC with TB | ||||||
| Yes | 121 (89.6) | 14 (10.4) | 3.808 (1.68–8.61) | 0.001 | 3.128 (1.21–8.06) | 0.018 |
| No | 362 (97.1) | 11 (2.9) | 1 | 0.320 (0.12–0.82) | ||
| Monthly income of family (PKRs) | ||||||
| < 5000 | 10 (83.3) | 2 (16.7) | 4.113 (0.85–19.86) | 0.078 | ||
| 6000–10,000 | 148 (96.7) | 5 (3.3) | 0.566 (0.20–1.53) | 0.264 | ||
| 11,000–20,000 | 239 (94.5) | 14 (5.5) | 1.299 (0.57–2.92) | 0.526 | – | – |
| > 20,000 | 86 (95.6) | 4 (4.4) | 1 | 0.818 | ||
| Education of caregiver | ||||||
| No formal education | 217 (91.6) | 20 (8.4) | 4.903 (1.81–13.27) | 0.002 | 0.623 (0.11–3.30) | 0.579 |
| Primary | 121 (98.4) | 2 (1.6) | 0.260 (0.06–1.12) | 0.071 | – | – |
| Secondary | 76 (98.7) | 1 (1.3) | 0.223 (0.03–1.67) | 0.145 | – | – |
| College | 35 (94.6) | 2 (5.4) | 1 | 0.888 | – | – |
| Graduation | 34 (100) | 00 | – | – | – | – |
