Fig. 2From: TLR9 polymorphism correlates with immune activation, CD4 decline and plasma IP10 levels in HIV patientsTLR9 1635AA genotype is associated with higher T cell immune activation. Immune activation was determined as CD38+ HLA-DR+ cells in CD4 and CD8 populations by flow cytometry. Immune activation in (a) CD8+ or (b) CD4+ T cells in TLR9 1635AA versus AG/GG genotype. (c) CD4 T cell apoptosis determined by z-VAD-FITC staining in TLR9 1635AA vs AG/GG groups. (d) Immune activation in CD8 T cells between 1635AA, AG or GG genotypes. (e) Comparison of plasma viremia between TLR9 1635AA or AG/GG genotypes. One tailed student’s t-test or Kruskal-Wallis test was used for statistical analysisBack to article page