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Table 3 Cox proportional hazards analysis of factors associated with incident tuberculosis (N = 62,983)

From: Effect of isoniazid preventive therapy on tuberculosis incidence and associated risk factors among HIV infected adults in Tanzania: a retrospective cohort study

Characteristic Unadjusted Adjusted
HR 95% CI aHR 95% CI
Age (years)
 15–25 1.0   1.0  
 26–35 1.6 1.3–1.9 1.6 1.0–2.4
 36–45 2.1 1.8–2.5 1.6 1.2–2.2
 45+ 2.2 1.7–2.6 1.3 0.9–2.0
Sex
 Females 1.0   1.0  
 Males 2.4 2.2–2.6 1.8 1.7–1.9
Marital status
 Single 1.0   1.0  
 Married/co-habiting 0.8 0.7–0.9 0.9 0.8–1.0
 Widowed/divorced 1.1 1.0–1.2 0.9 0.8–1.1
BMI categories (Kg/m2)
 Underweight (< 18.5) 2.5 2.3–2.7 1.8 1.5–2.1
 Normal (18.5–24.5) 1.0   1.0  
 Overweight (25–29.9) 0.5 0.4–0.6 0.7 0.6–0.8
 Obese (≥30) 0.4 0.3–0.4 0.5 0.4–0.7
CD4 categories (cells/μl)
  < 200 1.0   1.0  
 200–350 0.5 0.5–0.6 0.7 0.6–0.8
  > 350 0.3 0.3–0.4 0.5 0.4–0.6
WHO clinical staging of HIV
 I 1.0   1.0  
 II 2.0 1.7–2.3 1.4 1.2–1.6
 III 4.4 3.9–5.0 2.7 2.2–3.2
 IV 5.3 4.5–6.1 2.6 1.8–3.9
Cotrimoxazole use
 No 1.0   1.0  
 Yes 2.4 1.9–3.1 2.2 1.3–3.9
IPT status
 Ever 0.7 0.6–0.7 0.6 0.4–0.9
 Never 1.0    
ART status
 Ever 2.6 2.1–3.1 1.5 1.0–2.2
 Never 1.0   1.00  
Functional status at enrolment
 Working 1.0   1.0  
 Bedridden 1.8 1.2–2.8 2.5 2.0–3.2
 Ambulatory 6.1 5.3–7.0 1.2 0.4–3.2
  1. adjusted for the effect of age, sex, BMI, CD4 count, WHO stage, IPT use, ART status and Functional status at enrollment