|
Diagnostic & triage options
|
Presumptive TB cases receiving diagnostic test per yr.
|
True TB cases b starting treatment per year and case detection c %
|
False TB cases d starting TB treatment per year
|
Time between starting triage and receiving diagnosis (days)
|
Additional true TB cases starting treatment over base case per year a
|
Additional cost compared to base case per year a (US$ 000 s)
|
Cost per additional true TB patient diagnosed and treated (US$) a
|
|---|
|
Microscopy No Triage (base case)
|
10,281
|
1238 75%
|
543
|
6.0
|
0
|
0
|
0
|
|
Xpert No Triage
|
10,284
|
1375 83%
|
419
|
5.0
|
137 (57, 217)
|
581 (555, 607)
|
4242 (1372, 7111)
|
|
Xpert T2 Cough 1wk
|
9204
|
1370 83%
|
401
|
4.4
|
132 (54, 210)
|
536 (512, 559)
|
4057 (1313, 6802)
|
|
Xpert T3 Cough>3wks
|
7340
|
1290 80%
|
289
|
3.5
|
52 (−15, 119)
|
278 (266, 290)
|
5345 (1729, 8960)
|
|
Xpert T4 Clinical score
|
7365
|
1353 82%
|
296
|
3.5
|
114 (38, 190)
|
380 (363, 397)
|
3331 (1078, 5584)
|
|
Xpert T5 ANN
|
8477
|
1352 82%
|
341
|
4.0
|
114 (43, 187)
|
451 (431, 470)
|
3952 (1278, 6625)
|
|
Xpert T6 TPP optimal
|
5823
|
1354 82%
|
218
|
2.8
|
116 (45, 187)
|
172 (164, 179)
|
1481 (479, 2483)
|
|
Xpert T7 TPP minimal
|
6367
|
1366 83%
|
231
|
3.1
|
128 (56, 200)
|
301 (287, 314)
|
2349 (760, 3938)
|
- aNumbers in brackets represent 95% confidence limits
- bTB cases include both bacteriologically confirmed and clinically diagnosed cases that have TB
- cCase detection rate was calculated as the number of true TB cases identified through the complete triage and diagnostic algorithm, divided by the number of TB cases in the presumptive-TB case population calculated from the assumed TB prevalence (Table 2)
- dFalse TB cases are individuals diagnosed with TB and placed on TB treatment, but do not have TB (false positives)
