|
Diagnostic & triage options
|
Presumptive TB cases receiving diagnostic test per yr.
|
True TB cases b starting treatment per year and case detection % c
|
False TB cases d starting TB treatment per year
|
Time between starting triage and receiving diagnosis (days)
|
Additional true TB cases starting treatment over base case per year a
|
Additional cost compared to base case per year a (US$ 000 s)
|
Cost per additional true TB patient diagnosed and treated n(US$) a
|
|---|
|
Microscopy No Triage (base case)
|
10,281
|
1238 75%
|
543
|
6.0
|
0
|
0
|
0
|
|
Xpert No Triage
|
10,284
|
1375 83%
|
419
|
5.0
|
137 (57, 217)
|
581 (555, 607)
|
4242 (1372, 7111)
|
|
Xpert T2 Cough 1wk
|
8411
|
1197 72%
|
340
|
4.0
|
−41 (−118, 36)
|
233 (223, 244)
|
No benefit over base
|
|
Xpert T3 Cough>3wks
|
5183
|
878 53%
|
193
|
2.4
|
−360 (− 439, −281)
|
− 393 (− 410, − 375)
|
No benefit over base
|
|
Xpert T4 Clinical score
|
5470
|
1148 70%
|
191
|
2.5
|
−90 (−166, −14)
|
−51 (−53, −49)
|
No benefit over base
|
|
Xpert T5 ANN
|
7469
|
1369 82%
|
285
|
3.5
|
131 (39, 223)
|
367 (351, 384)
|
2805 (907, 4703)
|
|
Xpert T6 TPP optimal
|
3290
|
1320 80%
|
75
|
1.5
|
82 (2, 162)
|
−49 (−52, −47)
|
− 604 (−1012, − 195)
|
|
Xpert T7 TPP minimal
|
4046
|
1245 76%
|
121
|
1.8
|
7 (−74, 88)
|
−54 (−56, −52)
|
Minimal benefit over base case
|
- aNumbers in brackets represent 95% confidence limits
- bTrue TB cases include both bacteriologically confirmed and clinically diagnosed cases that have TB
- cCase detection rate calculated as the number of true TB cases identified through the complete triage and diagnostic algorithm, divided by the number of TB cases in the presumptive-TB case population calculated from the assumed TB prevalence (Table 2)
- dFalse TB cases are individuals diagnosed with TB and placed on TB treatment, but do not have TB (false positives)
