Diagnostic & triage options | Presumptive TB cases receiving diagnostic test per yr. | True TB cases b starting treatment per year and case detection % c | False TB cases d starting TB treatment per year | Time between starting triage and receiving diagnosis (days) | Additional true TB cases starting treatment over base case per year a | Additional cost compared to base case per year a (US$ 000 s) | Cost per additional true TB patient diagnosed and treated n(US$) a |
---|---|---|---|---|---|---|---|
Microscopy No Triage (base case) | 10,281 | 1238 75% | 543 | 6.0 | 0 | 0 | 0 |
Xpert No Triage | 10,284 | 1375 83% | 419 | 5.0 | 137 (57, 217) | 581 (555, 607) | 4242 (1372, 7111) |
Xpert T2 Cough 1wk | 8411 | 1197 72% | 340 | 4.0 | −41 (−118, 36) | 233 (223, 244) | No benefit over base |
Xpert T3 Cough>3wks | 5183 | 878 53% | 193 | 2.4 | −360 (− 439, −281) | − 393 (− 410, − 375) | No benefit over base |
Xpert T4 Clinical score | 5470 | 1148 70% | 191 | 2.5 | −90 (−166, −14) | −51 (−53, −49) | No benefit over base |
Xpert T5 ANN | 7469 | 1369 82% | 285 | 3.5 | 131 (39, 223) | 367 (351, 384) | 2805 (907, 4703) |
Xpert T6 TPP optimal | 3290 | 1320 80% | 75 | 1.5 | 82 (2, 162) | −49 (−52, −47) | − 604 (−1012, − 195) |
Xpert T7 TPP minimal | 4046 | 1245 76% | 121 | 1.8 | 7 (−74, 88) | −54 (−56, −52) | Minimal benefit over base case |