Effect of laminar air flow and building construction on aspergillosis in acute leukemia patients: a retrospective cohort study

Table 5 Multivariate analysis of the incidence of aspergillosis

variables	Adjusted HR with model 1^a	p value	Adjusted HR with model 2^b	p value
Neutropenia	0.45	0.362
treatment period^c
before construction (phase A)	1.97	0.463	1.76	0.540
during construction (phase B)	3.42	0.184	3.60	0.170
the late period after moving (phase D)	5.65	0.035	5.28	0.030
antifungal prophylaxis^d	0.88	0.818	0.82	0.800
ALL vs AML	0.46	0.348	0.56	0.480
age	0.81	0.709	0.86	0.690

AML denotes acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; HR, hazard ratio
^aModel 1 is a Cox proportional hazards ratio model with time-dependent covariates
^bModel 2 is a Fine and Gray proportional hazard regression model
^cHR is calculated by comparison of the incidence in each period with in the early period after moving
^dHR is the ratio of the incidence in patients who received fluconazole with mold-active agent prophylaxis with the incidence in patients who received fluconazole-only prophylaxis

ISSN: 1471-2334