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Table 1 Estimated rates in severe HFMD cases by time, regions, and population(per 1000 000 people, 95% confidence internal)a

From: Surveillance for severe hand, foot, and mouth disease from 2009 to 2015 in Jiangsu province: epidemiology, etiology, and disease burden

Years

Severe illness rate

Mortality rates

Case-severity rates

Severity−fatality rate

Case−fatality rates

Severity-PICU admission rates

Severity-hospitalization rates

Year

 2009

4.60(4.14–5.10)

0.08(0.03–0.16)

4205(3783–4661)

17,000(6889–35,350)

71.47(28.97–148.60)

33,990(18420–57,790)

892,400(797800–995,100)

 2010

16.69(15.79–17.60)

0.27(0.17–0.41)

1488(1408–1571)

16,290(10350–24,480)

242.40(154.10–364.20)

44,220(33810–56,880)

918,500(867300–972,000)

 2011

25.97(24.86–27.12)

0.24(0.15–0.37)

1779(1703–1858)

9300(5765–14,250)

165.50(102.60–253.60)

60,210(50250–71,580)

882,500(842500–924,000)

 2012

18.57(17.64–19.54)

0.14(0.07–2.42)

1268(1205–1334)

74,908(3943–13,030)

95.09(50.00–165.30)

79,070(65630–94,490)

909,300(861500–959,600)

 2013

10.42(9.72–11.15)

0.05(0.02–0.12)

8559(7990–9158)

4848(1541–11,700)

41.05(13.19–100.10)

167,300(141100–197,000)

865,500(803700–930,700)

 2014

20.73(19.75–21.75)

0.08(0.03–0.16)

9848(9380–10,330)

3645(1477–7582)

35.90(14.55–74.66)

84,450(71260–99,390)

925,300(879700–972,600)

 2015

4.66(4.20–5.15)

0.01(0.00–0.06)

3903(3520–4315)

2695(134.9–13,290)

10.52(0.52–51.88)

70,080(46750–101,200)

946,100(850900–1,049,000)

Total

14.54(14.22–14.86)

0.12(0.10–0.16)

10,520(10290–10,760)(10,290–10,760)

8506(6657–10,720)

242.40(154.10–364.20)

76,430(70550–82,680)

903,700(883000–924,700)

P value

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

Regions

 Southern

25.81(25.14–26.49)

0.11(0.07–0.16)

13,290(12950–13,640)

4294(2815–6292)

57.08(37.42–83.63)

4920(43640–55,280)

912,500(887700–937,800)

 Central

3.41(3.08–3.75)

0.05(0.02–0.11)

2764(2502–3046)

15,110(6126–31,430)

41.77(16.93–86.89)

73,050(49850–103,500)

856,400(768900–951,200)

 Northern

9.26(8.87–9.68)

0.18(0.13–0.24)

10,270(9828–10,730))

18,920(13580–25,710)

194.40(139.50–264.00)

152,900(136500–170,700)

888,400(847900–930,400)

p value

p < 0.001

p < 0.05

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

Age groups

 < 6 months

27.52(21.83–34.25)

0.00(0.00–0.00)

14,350(11390–17,870)

0.00(0.00–0.00)

0.00(0.00–0.00)

157,900(85550–268,400)

868,400(677100–1,098,000)

 6-11 months

313.9(293.5–335.4)

7.24(4.55–10.99)

11,280(10550–12,050)

23,070(14490–34,990)

260.30(163.50394.90)

144,200(120500–171,200)

899,700(838200–964,500)

 12-23 months

502.1(484.3–520.5)

5.43(3.18–7.58)

14,200(13690–14,720)

10,820(7529–15,090)

153.70(106.90–214.30)

81,500(71690–92,300)

905,600(871800–940,400)

 24-35 months

304.4(290.3–318.9)

1.57(0.77–2.88)

11,350(10820–11,890)

5161(2517–9470)

58.56(28.56–107.50)

59,630(48790–71,960)

897,400(853700–942,700)

 36-47 months

222.6(210.5–235.3)

1.44(0.67–2.74)

8933(8446–9442)

6472(3006–12,290)

57.82(26.85–109.80)

58,250(45920–72,930)

904,500(852700–958,700)

 48-59 months

114.8(106.1–124.00)

0.00(0.00–0.00)

7172(6628–7749)

0.00(0.00–0.00)

0.00(0.00–0.00)

41,270(27530–59,610)

907,900(835800–984,700)

 ≥60 months

0.93(0.85–1.02)

0.00(0.00–0.00)

5413(4946–5911)

0.00(0.00–0.00)

0.00(0.00–0.00)

64,050(44290–89,800)

919,400(836900–1,008,000)

P value

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.001

P > 0.05

Gender

 Male

18.62(18.12–19.13)

0.18(0.13–0.23)

11,140(10840–11,450)

9492(7100–12,450)

105.80(79.11–138.70)

78,460(71090–86,390)

905,500(879800–931,700)

 female

10.39(10.01–10.78)

0.07(0.04–0.11)

9552(9206–9909)

6709(4159–10,280)

64.09(39.73–98.22)

72,740(63300–83,200)

900,400(866000–935,900)

P value

p < 0.001

p < 0.001

P > 0.05

P > 0.05

p < 0.001

P > 0.05

P > 0.05

  1. aThe specific numerator and denominator were shown in Additional file 1: Table S1