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Table 3 Diagnostic utility of pleural IGRA, ADA, CEA and their integrations for the discriminating diagnosis of TPE and MPE

From: Pleural IFN-γ release assay combined with biomarkers distinguished effectively tuberculosis from malignant pleural effusion

Assays TPE MPE Sensitivity (95%CI) Specificity (95%CI) PPV (95%CI) NPV (95%CI)
n Positivity, n(%) n Positivity, n(%)
Pleural IGRA or ADA 138 133 (96.38) 58 41 (70.69) 0.96 (0.92–0.99) 0.29 (0.18–0.43) 0.76 (0.69–0.83) 0.77 (0.55–0.92)
Pleural IGRA and ADA 138 113 (81.88) 58 1 (1.72) 0.82 (0.74–0.88) 0.98 (0.91–1.00) 0.99 (0.95–1.00) 0.70 (0.58–0.79)
Pleural IGRA or CEA 128 127 (99.21) 53 37 (69.81) 0.99 (0.96–1.00) 0.31 (0.18–0.44) 0.77 (0.70–0.84) 0.94 (0.71–1.00)
Pleural IGRA and CEA 128 111 (86.72) 53 0 (0) 0.87 (0.80–0.92) 1.00 (0.93–1.00) 1.00 (0.97–1.00) 0.76 (0.64–0.85)
  1. Abbreviations: IGRA IFN-γ release assay, ADA adenosine deaminase, CEA arcinoembryonic antigen, PPV positive predictive value, NPV negative predictive value. The optimal cutoff values of the pleural ADA, CEA, IGRA stimulated with ESAT6 and peptide were 35.0 IU/L, 2.02 μg/L, 87 SFCs and 62.5 SFCs respectively