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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Pleural IFN-γ release assay combined with biomarkers distinguished effectively tuberculosis from malignant pleural effusion

Fig. 1

The PFMCs IGRA shows higher diagnostic performance to discriminate TPE and MPE. a The PBMCs from TPE (n = 143) and MPE (n = 58) patients were stimulated with ESAT-6 protein and ESAT-6/CFP-10 peptide pool, after 24hs incubation, IFN-γ-producing cells were determined using ELISPOT reader. b The PFMCs isolated from pleural effusion were stimulated with ESAT-6 and peptide pool, and the differences of SFCs were compared between TPE (n = 143) and MPE (n = 58) patients. The unpaired t test was used for the analysis. c, d ROC analysis was conducted to determine the power of IGRA in discriminating TPE and MPE in PBMCs (c) and PFMCs (d). The AUC of both ESAT-6 and peptide induced IFN-γ responses was determined

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