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Table 3 Comparison of the groups with high and low IFN-γ and IL-6 levels among the patients on ART at diagnosis of HIV infection

From: Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study

  High IFN-γ Low IFN-γ P-value High IL-6 Low IL-6 P-value
Clinical categories    0.7550    0.4122
 Acute HIV infection 7 (18%) 26 (17%)   4 (11%) 29 (19%)  
 Chronic HIV infection, Category A/B 21 (54%) 89 (60%)   25 (66%) 85 (57%)  
 Category C 11 (28%) 34 (23%)   9 (24%) 36 (24%)  
CD4+ cell count (cell/μL), median [IQR] 265 [71–393] 253 [116–393] 0.9986 261 [107–386] 253 [104–398] 0.6920
HIV-1-RNA level (copies/mL), median [IQR] 96,750 [25,050–789,500] 105,000 [26,725–462,250] 0.9956 79,150 [25,475–373,250] 101,500 [26,100–491,500] 0.5009
Comorbidities
 Chronic renal disease (n, %) 0 (0%) 3 (2%) 1.0000 1 (2%) 2 (1%) 0.5089
 Chronic hepatitis B (n, %) 2 (5%) 12 (8%) 0.7391 2 (5%) 12 (8%) 0.7384
 Dyslipidemia (n, %) 2 (5%) 15 (9%) 0.5327 3 (7%) 14 (9%) 1.0000
 Hypertension (n, %) 0 (0%) 4 (3%) 0.5833 2 (5%) 2 (1%) 0.1949
 Diabetes mellitus (n, %) 0 (0%) 5 (3%) 0.5855 3 (7%) 2 (1%) 0.0635
  1. Abbreviations: IQR = interquartile range, HIV-1 = human immunodeficiency virus 1