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Table 1 Phenotypic resistance by MGIT 960 system to anti-TB drugs and genotypic screening of mutations in HSR-rpoB, katG315 and inhA-RR among 242 clinical M. tuberculosis isolates

From: Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis

Phenotypic resistance to anti-TB drug No. of isolates tested Number of isolates detected by gMTBDR+ with a mutation in
HSR-rpoB katG315 (S315 T) inhA-RR
None 64 0 0 0
SM 15 0 0 0
INH 51 0 15 21a
INH + SM 75 2 58 11b
INH + EMB 26 1 10 2b
INH + SM + EMB 11 1 6 0
  1. gMTBDR+, GenoType MTBDRplus assay; HSR-rpoB, 81-base pair hot-spot region of rpoB gene; katG315 (S315 T), S315 T mutation at katG codon 315; inhA-RR, upstream regulatory region of inhA gene
  2. SM streptomycin, INH isoniazid, EMB ethambutol
  3. a20 isolates contained − 15 C/T and 1 isolate contained − 8 T/A mutation
  4. bAll isolates contained − 15 C/T mutation