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Table 5 Frequencies of laboratory tests and patient monitoring visits per patient and model according to the Nigerian DR-TB guidelines

From: Cost of three models of care for drug-resistant tuberculosis patients in Nigeria

   Model A Model B Model C
  Unit Frequency in intensive phase Frequency in continuation phase Frequency in intensive phase Frequency in continuation phase Frequency in intensive phase Frequency in continuation phase
I. DR-TB Diagnostic tests
 GeneXpert Test 1 1 1
 Sputum smear Smear 1 1 1
 Culture – Liquid Test 1 1 1
 1st and 2nd line DST - Solid culture Test 1 1 1
II. Baseline tests & routine laboratory tests
 X-ray Test 2 2 2 2 2 2
 ENT consultation Consult 1 1 1
 Audiometry test Test 9 9 9
 E, U, Cr Test 8 8 8
 Thyroid function test Test 2 2 2 2 2 2
 LFT Test 3 4 3 4 3 4
 HIV Test Test 1 1 1
 Pregnancy test Test 0.5 0.5 0.5
III. Drugs
 Pyrazinamide 400 mg Tablet 972 1488 972 1488 972 1488
 Kanamycin 1 g vial Vial 243 243 243
 Levofloxacin 250 mg Caplet 729 1116 729 1116 729 1116
 Prothionamide 250 mg Tablet 729 1116 729 1116 729 1116
 Cycloserine 250 mg Capsule 729 1116 729 1116 729 1116
 Pyridoxine 10 mg Tablet 729 1116 729 1116 729 1116
IV. Inpatient stay
 Inpatient hospitalization days Bed day 243 152
V. Outpatient consultations and supervision
 Consultation at treatment center /Monthly clinic visit Visit 12 3 12 8 12
 Visits to collect medication at DOT center/ DOT at DOT center Visit 24 6 24 16 24
 Home visit - by DOT officer Home visit 24 91 24 243 24
 Home visit by DR TB focal person Home visit 12 3 12 8 12
 Home visit by TBL supervisor Home visit 12 3 12 8 12
 Quarterly state team meeting Meeting 4 1 4 3 4
 Quarterly state team home visit Home visit 4 2 4 2 4
VI. Follow-up DR-TB testing
 Sputum smear Smear 8 12 8 12 8 12
 Culture - Liquid Test 8 6 8 6 8 6
 1st and 2nd line DST - Solid culture Test 0.2^ 0 0.2^ 0 0.2a 0
  1. List of abbreviations: Cr creatinine, DOT directly observed treatment, DR drug resistant, DST drug susceptibility testing, E electrolytes, ENT ear nose throat, TB tuberculosis, TBL tuberculosis and leprosy, U urea, LFT liver function test,
  2. aA conservative estimate of DR-TB patients who are still culture positive after four months of DR-TB treatment and thus require repeat second-line DST